CDB25:0003153 APP — LRP10

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.

Molecular neurodegeneration, 2012; PubMed, Homo sapiens APP — Homo sapiens LRP10

ABSTRACT: The Aβ peptide that accumulates in Alzheimer's disease (AD) is derived from amyloid precursor protein (APP) following proteolysis by β- and γ-secretases. Substantial evidence indicates that alterations in APP trafficking within the secretory and endocytic pathways directly impact the interaction of APP with these secretases and subsequent Aβ production. Various members of the low-density lipoprotein receptor (LDLR) family have been reported to play a role in APP trafficking and processing and are important risk factors in AD. We recently characterized a distinct member of the LDLR family called LDLR-related protein 10 (LRP10) that shuttles between the trans-Golgi Network (TGN), plasma membrane (PM), and endosomes. Here we investigated whether LRP10 participates in APP intracellular trafficking and Aβ production.

Basic Information on APP

Ligand Name: amyloid beta precursor protein

Other Symbols: AD1, alpha-sAPP

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: APP

GeneCards: APP

HGNC Gene Group: Receptor ligands

Functional Annotations for APP

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for APP

APP — CD74 ・ APP — FPR2 ・ APP — GPC1 ・ APP — LRP1 ・ APP — ADRA2A ・ APP — AGER ・ APP — APLP1 ・ APP — APLP2 ・ APP — CNTN3 ・ APP — CNTN4 ・ APP — CNTN5 ・ APP — DCC ・ APP — LRP2 ・ APP — LRP4 ・ APP — LRP6 ・ APP — NOTCH1 ・ APP — NOTCH2 ・ APP — RPSA ・ APP — TRPC6

Basic Information on LRP10

Receptor Name: LDL receptor related protein 10

Other Symbols: DKFZP564C1940, MGC8675, LRP9, MST087, MSTP087

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: LRP10

GeneCards: LRP10

HGNC Gene Group: Low density lipoprotein receptors

Functional Annotations for LRP10

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LRP10