CDB20:0002582 ANGPTL2 — ITGA5

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.

Osteoarthritis and cartilage, 2018; PubMed, Mus Musculus Angptl2 — Mus Musculus Itga5

ABSTRACT: Chondrocyte differentiation is crucial for long bone growth. Many cartilage extracellular matrix (ECM) proteins reportedly contribute to chondrocyte differentiation, indicating that mechanisms underlying chondrocyte differentiation are likely more complex than previously appreciated. Angiopoietin-like protein 2 (ANGPTL2) is a secreted factor normally abundantly produced in mesenchymal lineage cells such as adipocytes and fibroblasts, but its loss contributes to the pathogenesis of lifestyle- or aging-related diseases. However, the function of ANGPTL2 in chondrocytes, which are also differentiated from mesenchymal stem cells, remains unclear. Here, we investigate whether ANGPTL2 is expressed in or functions in chondrocytes.

Basic Information on ANGPTL2

Ligand Name: angiopoietin like 2

Other Symbols: ARP2, HARP

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: ANGPTL2

GeneCards: ANGPTL2

HGNC Gene Group: Fibrinogen C domain containing, Angiopoietin like family

Functional Annotations for ANGPTL2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for ANGPTL2

ANGPTL2 — ITGB1 ・ ANGPTL2 — LILRB2 ・ ANGPTL2 — LILRB3 ・ ANGPTL2 — LILRB5 ・ ANGPTL2 — MCAM

Basic Information on ITGA5

Receptor Name: integrin subunit alpha 5

Other Symbols: FNRA, CD49e

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: ITGA5

GeneCards: ITGA5

HGNC Gene Group: CD molecules, Integrins

Functional Annotations for ITGA5

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGA5

ADAM15 — ITGA5 ・ ADAM17 — ITGA5 ・ ANGPT1 — ITGA5 ・ COL18A1 — ITGA5 ・ CCN2 — ITGA5 ・ FBN1 — ITGA5 ・ FGA — ITGA5 ・ FN1 — ITGA5 ・ L1CAM — ITGA5 ・ SPP1 — ITGA5 ・ VTN — ITGA5 ・ CCN4 — ITGA5 ・ CXCL12 — ITGA5 ・ PLA2G2A — ITGA5 ・ SPON2 — ITGA5 ・ AGGF1 — ITGA5 ・ ANGPT2 — ITGA5 ・ ANGPTL4 — ITGA5 ・ CCN3 — ITGA5 ・ CD40LG — ITGA5 ・ COL4A3 — ITGA5 ・ IL1B — ITGA5 ・ MIA — ITGA5 ・ TGM2 — ITGA5 ・ THBS4 — ITGA5 ・ THY1 — ITGA5