CDB25:0003081 AGGF1 — ITGA5

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial Cell Functions and Angiogenesis.

Arteriosclerosis, thrombosis, and vascular biology, 2021; PubMed, Homo sapiens AGGF1 — Homo sapiens ITGA5

ABSTRACT: Angiogenic factor AGGF1 (angiogenic factor with G-patch and FHA [Forkhead-associated] domain 1) promotes angiogenesis as potently as VEGFA (vascular endothelial growth factor A) and regulates endothelial cell (EC) proliferation, migration, specification of multipotent hemangioblasts and venous ECs, hematopoiesis, and vascular development and causes vascular disease Klippel-Trenaunay syndrome when mutated. However, the receptor for AGGF1 and the underlying molecular mechanisms remain to be defined.

Basic Information on AGGF1

Ligand Name: angiogenic factor with G-patch and FHA domains 1

Other Symbols: VG5Q, HSU84971, FLJ10283, GPATC7, GPATCH7

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: AGGF1

GeneCards: AGGF1

HGNC Gene Group: G-patch domain containing

Functional Annotations for AGGF1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for AGGF1

AGGF1 — ITGB1

Basic Information on ITGA5

Receptor Name: integrin subunit alpha 5

Other Symbols: FNRA, CD49e

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: ITGA5

GeneCards: ITGA5

HGNC Gene Group: CD molecules, Integrins

Functional Annotations for ITGA5

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGA5

ADAM15 — ITGA5 ・ ADAM17 — ITGA5 ・ ANGPT1 — ITGA5 ・ COL18A1 — ITGA5 ・ CCN2 — ITGA5 ・ FBN1 — ITGA5 ・ FGA — ITGA5 ・ FN1 — ITGA5 ・ L1CAM — ITGA5 ・ SPP1 — ITGA5 ・ VTN — ITGA5 ・ ANGPTL2 — ITGA5 ・ CCN4 — ITGA5 ・ CXCL12 — ITGA5 ・ PLA2G2A — ITGA5 ・ SPON2 — ITGA5 ・ ANGPT2 — ITGA5 ・ ANGPTL4 — ITGA5 ・ CCN3 — ITGA5 ・ CD40LG — ITGA5 ・ COL4A3 — ITGA5 ・ IL1B — ITGA5 ・ MIA — ITGA5 ・ TGM2 — ITGA5 ・ THBS4 — ITGA5 ・ THY1 — ITGA5