CDB15:0001481 TIMP3 — KDR

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2.

Nature medicine, 2003; PubMed, Homo sapiens TIMP3 — Homo sapiens KDR

ABSTRACT: Tissue inhibitor of metalloproteinases-3 (TIMP3) is one of four members of a family of proteins that were originally classified according to their ability to inhibit matrix metalloproteinases (MMP). TIMP3, which encodes a potent angiogenesis inhibitor, is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. In this study we demonstrate the ability of TIMP3 to inhibit vascular endothelial factor (VEGF)-mediated angiogenesis and identify the potential mechanism by which this occurs: TIMP3 blocks the binding of VEGF to VEGF receptor-2 and inhibits downstream signaling and angiogenesis. This property seems to be independent of its MMP-inhibitory activity, indicating a new function for this molecule.

Basic Information on TIMP3

Ligand Name: TIMP metallopeptidase inhibitor 3

Other Symbols: SFD

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: TIMP3

GeneCards: TIMP3

HGNC Gene Group: Tissue inhibitor of metallopeptidases

Functional Annotations for TIMP3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for TIMP3

TIMP3 — AGTR2 ・ TIMP3 — ITGA7 ・ TIMP3 — LRP1 ・ TIMP3 — MMP2

Basic Information on KDR

Receptor Name: kinase insert domain receptor

Other Symbols: FLK1, VEGFR, VEGFR2, CD309

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: KDR

GeneCards: KDR

HGNC Gene Group: Receptor kinases, CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for KDR

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for KDR

COL18A1 — KDR ・ VEGFD — KDR ・ GREM1 — KDR ・ VEGFA — KDR ・ VEGFC — KDR ・ BSG — KDR ・ DCN — KDR ・ PTN — KDR ・ SCUBE2 — KDR