CDB15:0001480 TIMP3 — AGTR2

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Tissue inhibitor of metalloproteinases-3 interacts with angiotensin II type 2 receptor and additively inhibits angiogenesis.

Cardiovascular research, 2008; PubMed, Homo sapiens TIMP3 — Homo sapiens AGTR2

ABSTRACT: The tissue inhibitors of metalloproteinases (TIMPs) are complex molecules with both pro- and anti-tumour effects. Thus, their diverse expression could be because of their multifunctional properties with respect to tumour growth, angiogenesis, apoptosis, and other biological functions. Previous data have shown that TIMPs bind tightly to most matrix metalloproteinases, although the pathway that mediates angiostatic activity has not been fully established.

Basic Information on TIMP3

Ligand Name: TIMP metallopeptidase inhibitor 3

Other Symbols: SFD

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: TIMP3

GeneCards: TIMP3

HGNC Gene Group: Tissue inhibitor of metallopeptidases

Functional Annotations for TIMP3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for TIMP3

TIMP3 — KDR ・ TIMP3 — ITGA7 ・ TIMP3 — LRP1 ・ TIMP3 — MMP2

Basic Information on AGTR2

Receptor Name: angiotensin II receptor type 2

Other Symbols: AT2, MRX88

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: AGTR2

GeneCards: AGTR2

HGNC Gene Group: 7TM proteins

Functional Annotations for AGTR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for AGTR2

AGT — AGTR2