CDB25:0004244 SCUBE2 — KDR

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Endothelial SCUBE2 Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis.

Arteriosclerosis, thrombosis, and vascular biology, 2017; PubMed, Homo sapiens SCUBE2 — Homo sapiens KDR

ABSTRACT: Vascular endothelial growth factor (VEGF), a major mediator of angiogenesis, exerts its proangiogenic action by binding to VEGFR2 (VEGF receptor 2), the activity of which is further modulated by VEGFR2 coreceptors such as neuropilins. However, whether VEGFR2 is regulated by additional coreceptors is not clear. To investigate whether SCUBE2 (signal peptide-CUB-EGF domain-containing protein 2), a peripheral membrane protein expressed in vascular endothelial cells (ECs) known to bind other signaling receptors, functions as a VEGFR2 coreceptor and to verify the role of SCUBE2 in the VEGF-induced angiogenesis.

Basic Information on SCUBE2

Ligand Name: signal peptide, CUB domain and EGF like domain containing 2

Other Symbols: Cegf1, Cegb1, FLJ16792

Ligand Location: secreted based on perplexity, uniprot, cell membrane based on perplexity

HGNC Gene Symbol Report: SCUBE2

GeneCards: SCUBE2

HGNC Gene Group: MicroRNA host genes

Functional Annotations for SCUBE2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for SCUBE2

SCUBE2 — CAV1 ・ SCUBE2 — PTCH1

Basic Information on KDR

Receptor Name: kinase insert domain receptor

Other Symbols: FLK1, VEGFR, VEGFR2, CD309

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: KDR

GeneCards: KDR

HGNC Gene Group: Receptor kinases, CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for KDR

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for KDR

COL18A1 — KDR ・ VEGFD — KDR ・ GREM1 — KDR ・ TIMP3 — KDR ・ VEGFA — KDR ・ VEGFC — KDR ・ BSG — KDR ・ DCN — KDR ・ PTN — KDR