CDB25:0004373 TGM2 — LRP6

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Extracellular transglutaminase 2 activates beta-catenin signaling in calcifying vascular smooth muscle cells.

FEBS letters, 2008; PubMed, Mus Musculus Tgm2 — Mus Musculus Lrp6

ABSTRACT: Accumulation of transglutaminase 2 (TG2) is often associated with mineral deposits in vasculature. Here, we demonstrate that purified TG2 stimulated a 3-fold increase in matrix mineralization and up-regulation of osteoblastic markers in cultured primary vascular smooth muscle cells (VSMCs). Extracellular TG2 interacts with the low density lipoprotein related-protein 5 receptor and activates beta-catenin signaling in VSMCs. These results suggest that TG2 may promote vascular calcification by activating the beta-catenin signaling pathway.

Basic Information on TGM2

Ligand Name: transglutaminase 2

Other Symbols: TGC, TG2

Ligand Location: secreted based on hpa, uniprot, cell membrane based on hpa, uniprot

HGNC Gene Symbol Report: TGM2

GeneCards: TGM2

HGNC Gene Group: Transglutaminases

Functional Annotations for TGM2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for TGM2

TGM2 — ADGRG1 ・ TGM2 — ITGA4 ・ TGM2 — ITGA9 ・ TGM2 — ITGB1 ・ TGM2 — ITGB3 ・ TGM2 — SDC4 ・ TGM2 — ITGA5 ・ TGM2 — LRP5

Basic Information on LRP6

Receptor Name: LDL receptor related protein 6

Other Symbols: ADCAD2

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: LRP6

GeneCards: LRP6

HGNC Gene Group: Low density lipoprotein receptors

Functional Annotations for LRP6

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LRP6

APOB — LRP6 ・ CCN2 — LRP6 ・ DKK1 — LRP6 ・ DKK2 — LRP6 ・ IGFBP4 — LRP6 ・ RSPO1 — LRP6 ・ RSPO3 — LRP6 ・ SOST — LRP6 ・ WNT1 — LRP6 ・ WNT2 — LRP6 ・ WNT3A — LRP6 ・ WNT3 — LRP6 ・ WNT7A — LRP6 ・ DKK4 — LRP6 ・ SOSTDC1 — LRP6 ・ APP — LRP6 ・ DRAXIN — LRP6 ・ PTH — LRP6 ・ SELENOP — LRP6 ・ SMOC2 — LRP6 ・ WNT10A — LRP6 ・ WNT10B — LRP6 ・ WNT4 — LRP6 ・ WNT5A — LRP6 ・ WNT6 — LRP6 ・ WNT7B — LRP6 ・ WNT8A — LRP6 ・ WNT8B — LRP6 ・ WNT9A — LRP6 ・ WNT9B — LRP6