CDB25:0004318 SMOC2 — LRP6

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Targeting cancer stem cell signature gene SMOC-2 Overcomes chemoresistance and inhibits cell proliferation of endometrial carcinoma.

EBioMedicine, 2019; PubMed, Homo sapiens SMOC2 — Homo sapiens LRP6

ABSTRACT: Endometrial cancer is one of the most common gynecological malignancies and has exhibited an increasing incidence rate in recent years. Cancer stem cells (CSCs), which are responsible for tumor growth and chemoresistance, have been confirmed in endometrial cancer. However, it is still challenging to identify endometrial cancer stem cells to then target for therapy.

Basic Information on SMOC2

Ligand Name: SPARC related modular calcium binding 2

Other Symbols: SMAP2

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: SMOC2

GeneCards: SMOC2

HGNC Gene Group: EF-hand domain containing

Functional Annotations for SMOC2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for SMOC2

SMOC2 — FZD6

Basic Information on LRP6

Receptor Name: LDL receptor related protein 6

Other Symbols: ADCAD2

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: LRP6

GeneCards: LRP6

HGNC Gene Group: Low density lipoprotein receptors

Functional Annotations for LRP6

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LRP6

APOB — LRP6 ・ CCN2 — LRP6 ・ DKK1 — LRP6 ・ DKK2 — LRP6 ・ IGFBP4 — LRP6 ・ RSPO1 — LRP6 ・ RSPO3 — LRP6 ・ SOST — LRP6 ・ WNT1 — LRP6 ・ WNT2 — LRP6 ・ WNT3A — LRP6 ・ WNT3 — LRP6 ・ WNT7A — LRP6 ・ DKK4 — LRP6 ・ SOSTDC1 — LRP6 ・ APP — LRP6 ・ DRAXIN — LRP6 ・ PTH — LRP6 ・ SELENOP — LRP6 ・ TGM2 — LRP6 ・ WNT10A — LRP6 ・ WNT10B — LRP6 ・ WNT4 — LRP6 ・ WNT5A — LRP6 ・ WNT6 — LRP6 ・ WNT7B — LRP6 ・ WNT8A — LRP6 ・ WNT8B — LRP6 ・ WNT9A — LRP6 ・ WNT9B — LRP6