CDB25:0003488 DRAXIN — LRP6

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling.

Biochemical and biophysical research communications, 2009; PubMed, Mus Musculus Draxin — Mus Musculus Lrp6

ABSTRACT: A gene encoding a novel secreted protein in mice and humans was identified, and named Neucrin. Mouse Neucrin consists of 343 amino acids with a cysteine-rich domain in its carboxyl terminal region. The positions of 10 cysteine residues in the cysteine-rich domain are similar to those of Dickkopfs (Dkks), secreted Wnt antagonists. However, whereas Dkks have two cysteine-rich domains, Neucrin has only one. Neucrin as well as Dkks bound to LDL receptor-related protein 6 and inhibited the stabilization of cytosolic beta-catenin, indicating that Neucrin is an antagonist of canonical Wnt signaling. Mouse Neucrin expression was not detected in any major tissues in the adult, but was detected in developing neural tissues, including the brain and spinal cord. The expression pattern of Neucrin is distinct from that of any Dkk. Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues.

Basic Information on DRAXIN

Ligand Name: dorsal inhibitory axon guidance protein

Other Symbols: C1orf187, FLJ34999, Neucrin

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: DRAXIN

GeneCards: DRAXIN

HGNC Gene Group: unknown

Functional Annotations for DRAXIN

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for DRAXIN

DRAXIN — DCC

Basic Information on LRP6

Receptor Name: LDL receptor related protein 6

Other Symbols: ADCAD2

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: LRP6

GeneCards: LRP6

HGNC Gene Group: Low density lipoprotein receptors

Functional Annotations for LRP6

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LRP6

APOB — LRP6 ・ CCN2 — LRP6 ・ DKK1 — LRP6 ・ DKK2 — LRP6 ・ IGFBP4 — LRP6 ・ RSPO1 — LRP6 ・ RSPO3 — LRP6 ・ SOST — LRP6 ・ WNT1 — LRP6 ・ WNT2 — LRP6 ・ WNT3A — LRP6 ・ WNT3 — LRP6 ・ WNT7A — LRP6 ・ DKK4 — LRP6 ・ SOSTDC1 — LRP6 ・ APP — LRP6 ・ PTH — LRP6 ・ SELENOP — LRP6 ・ SMOC2 — LRP6 ・ TGM2 — LRP6 ・ WNT10A — LRP6 ・ WNT10B — LRP6 ・ WNT4 — LRP6 ・ WNT5A — LRP6 ・ WNT6 — LRP6 ・ WNT7B — LRP6 ・ WNT8A — LRP6 ・ WNT8B — LRP6 ・ WNT9A — LRP6 ・ WNT9B — LRP6