CDB25:0004119 POSTN — ITGB5

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility.

Cancer research, 2002; PubMed, Homo sapiens POSTN — Homo sapiens ITGB5

ABSTRACT: Periostin (PN) is a secreted protein that shares a structural homology to the axon guidance protein fasciclin I in insects. Previously, we reported that PN expression is up-regulated in epithelial ovarian tumors. We further examined the role of PN in ovarian cancer. PN is expressed in several normal tissues but not in normal ovaries and has a tendency for higher expression in fetal tissues. Ovarian cancer cells secrete PN, which can accumulate in malignant ascites of ovarian cancer patients. Purified recombinant PN supports adhesion of ovarian epithelial cells that can be inhibited by monoclonal antibodies against alpha(V)beta(3) or alpha(V)beta(5) integrin, but not by anti-beta(1) integrin antibody. Furthermore, alpha(V)beta(3) integrin, but not beta(1) integrins, colocalizes to the focal adhesion plaques formed on PN. Cells plated on PN form fewer stress fibers and are more motile compared with those plated on fibronectin. We propose PN functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins to support adhesion and migration of ovarian epithelial cells.

Basic Information on POSTN

Ligand Name: periostin

Other Symbols: OSF-2, PN, periostin

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: POSTN

GeneCards: POSTN

HGNC Gene Group: Gla domain containing

Functional Annotations for POSTN

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for POSTN

POSTN — ITGAV ・ POSTN — ITGB3 ・ POSTN — STAB1 ・ POSTN — STAB2

Basic Information on ITGB5

Receptor Name: integrin subunit beta 5

Other Symbols: N/A

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: ITGB5

GeneCards: ITGB5

HGNC Gene Group: Integrins

Functional Annotations for ITGB5

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGB5

ADAM9 — ITGB5 ・ CCN1 — ITGB5 ・ LTBP1 — ITGB5 ・ LTBP3 — ITGB5 ・ VTN — ITGB5 ・ FNDC5 — ITGB5 ・ SPP1 — ITGB5 ・ ANGPTL4 — ITGB5 ・ COL4A3 — ITGB5 ・ FCER2 — ITGB5 ・ IBSP — ITGB5 ・ ICAM4 — ITGB5 ・ MFGE8 — ITGB5 ・ THBS4 — ITGB5