CDB25:0004120 POSTN — STAB1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression.

Circulation, 2022; PubMed, Homo sapiens POSTN — Homo sapiens STAB1

ABSTRACT: Scavenger receptors Stabilin-1 (Stab1) and Stabilin-2 (Stab2) are preferentially expressed by liver sinusoidal endothelial cells. They mediate the clearance of circulating plasma molecules controlling distant organ homeostasis. Studies suggest that Stab1 and Stab2 may affect atherosclerosis. Although subsets of tissue macrophages also express Stab1, hematopoietic Stab1 deficiency does not modulate atherogenesis. Here, we comprehensively studied how targeting Stab1 and Stab2 affects atherosclerosis.

Basic Information on POSTN

Ligand Name: periostin

Other Symbols: OSF-2, PN, periostin

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: POSTN

GeneCards: POSTN

HGNC Gene Group: Gla domain containing

Functional Annotations for POSTN

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for POSTN

POSTN — ITGAV ・ POSTN — ITGB3 ・ POSTN — ITGB5 ・ POSTN — STAB2

Basic Information on STAB1

Receptor Name: stabilin 1

Other Symbols: KIAA0246, STAB-1, FEEL-1, CLEVER-1, FELE-1, FEX1, SCARH2

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: STAB1

GeneCards: STAB1

HGNC Gene Group: Scavenger receptors

Functional Annotations for STAB1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for STAB1

SPARC — STAB1 ・ TGFBI — STAB1