CDB25:0003837 L1CAM — FGFR1

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Fibronectin type III (FN3) modules of the neuronal cell adhesion molecule L1 interact directly with the fibroblast growth factor (FGF) receptor.

Molecular and cellular neurosciences, 2008; PubMed, Mus Musculus L1cam — Mus Musculus Fgfr1

ABSTRACT: The neuronal cell adhesion molecule (CAM) L1 promotes axonal outgrowth, presumably through an interaction with the fibroblast growth factor receptor (FGFR). The present study demonstrates a direct interaction between L1 fibronectin type III (FN3) modules I-V and FGFR1 immunoglobulin (Ig) modules II and III by surface plasmon resonance analysis. Binding of L1 to FGFR1 was enhanced by adenosine 5'-triphosphate (ATP), adenylylmethylenediphosphonate (AMP-PCP), and guanosine-5'-triphosphate (GTP), but not adenosine monophosphate (AMP). The L1-FN3 modules were capable of activating FGFR1, reflected by receptor phosphorylation, and this resulted in the induction of differentiation of primary neurons, reflected by neurite outgrowth. Furthermore, ATP modulated L1-induced neuronal differentiation and FGFR1 phosphorylation through regulation of the L1-FGFR1 interaction.

Basic Information on L1CAM

Ligand Name: L1 cell adhesion molecule

Other Symbols: HSAS1, SPG1, HSAS, MASA, MIC5, S10, CD171, NCAM-L1, CAML1

Ligand Location: secreted based on perplexity, cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: L1CAM

GeneCards: L1CAM

HGNC Gene Group: Ig-like cell adhesion molecule family, CD molecules, Fibronectin type III domain containing, Immunoglobulin superfamily domain containing

Functional Annotations for L1CAM

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for L1CAM

L1CAM — CNTN1 ・ L1CAM — EGFR ・ L1CAM — ERBB2 ・ L1CAM — ERBB3 ・ L1CAM — ITGA5 ・ L1CAM — ITGAV ・ L1CAM — ALCAM ・ L1CAM — ITGA2B ・ L1CAM — ITGA9 ・ L1CAM — ITGB1 ・ L1CAM — ITGB3 ・ L1CAM — L1CAM ・ L1CAM — NRP1

Basic Information on FGFR1

Receptor Name: fibroblast growth factor receptor 1

Other Symbols: FLT2, KAL2, H2, H3, H4, H5, CEK, FLG, BFGFR, N-SAM, CD331

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: FGFR1

GeneCards: FGFR1

HGNC Gene Group: Receptor kinases, CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for FGFR1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for FGFR1

FGF10 — FGFR1 ・ FGF16 — FGFR1 ・ FGF17 — FGFR1 ・ FGF18 — FGFR1 ・ FGF19 — FGFR1 ・ FGF1 — FGFR1 ・ FGF23 — FGFR1 ・ FGF2 — FGFR1 ・ FGF3 — FGFR1 ・ FGF4 — FGFR1 ・ FGF5 — FGFR1 ・ FGF6 — FGFR1 ・ FGF7 — FGFR1 ・ FGF8 — FGFR1 ・ FGF9 — FGFR1 ・ ANOS1 — FGFR1 ・ NCAM1 — FGFR1 ・ FGF20 — FGFR1 ・ FGF22 — FGFR1 ・ CCN2 — FGFR1 ・ CDH1 — FGFR1 ・ FAM3B — FGFR1 ・ FGF21 — FGFR1 ・ GREM1 — FGFR1 ・ MMP2 — FGFR1 ・ NECTIN1 — FGFR1 ・ PF4 — FGFR1