CDB20:0002805 L1CAM — ALCAM

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Influence of L1-CAM expression of breast cancer cells on adhesion to endothelial cells.

Journal of cancer research and clinical oncology, 2013; PubMed, Homo sapiens L1CAM — Homo sapiens ALCAM

ABSTRACT: Expression of the adhesion molecule L1-CAM (L1) has been shown to correlate with early recurrence in breast cancer. Here, we investigated whether L1-CAM expression of breast cancer cells might influence adherence to human pulmonary microvascular endothelial cells (HPMEC) and thus promote metastasis.

Basic Information on L1CAM

Ligand Name: L1 cell adhesion molecule

Other Symbols: HSAS1, SPG1, HSAS, MASA, MIC5, S10, CD171, NCAM-L1, CAML1

Ligand Location: secreted based on perplexity, cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: L1CAM

GeneCards: L1CAM

HGNC Gene Group: Ig-like cell adhesion molecule family, CD molecules, Fibronectin type III domain containing, Immunoglobulin superfamily domain containing

Functional Annotations for L1CAM

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for L1CAM

L1CAM — CNTN1 ・ L1CAM — EGFR ・ L1CAM — ERBB2 ・ L1CAM — ERBB3 ・ L1CAM — ITGA5 ・ L1CAM — ITGAV ・ L1CAM — FGFR1 ・ L1CAM — ITGA2B ・ L1CAM — ITGA9 ・ L1CAM — ITGB1 ・ L1CAM — ITGB3 ・ L1CAM — L1CAM ・ L1CAM — NRP1

Basic Information on ALCAM

Receptor Name: activated leukocyte cell adhesion molecule

Other Symbols: CD166, MEMD

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: ALCAM

GeneCards: ALCAM

HGNC Gene Group: Ig-like cell adhesion molecule family, CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for ALCAM

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ALCAM

CD6 — ALCAM ・ ALCAM — ALCAM ・ LGALS8 — ALCAM ・ S100A8 — ALCAM ・ S100A9 — ALCAM ・ S100B — ALCAM