CDB25:0003294 CDH1 — FGFR1

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Cdh2 stabilizes FGFR1 and contributes to primed-state pluripotency in mouse epiblast stem cells.

Scientific reports, 2015; PubMed, Mus Musculus Cdh1 — Mus Musculus Fgfr1

ABSTRACT: The cell adhesion molecule Cadherin 2 (Cdh2) plays important roles in somatic cell adhesion, proliferation and migration. Cdh2 is also highly expressed in mouse epiblast stem cells (mEpiSCs), but its function in these cells is unknown. To understand the function of Cdh2 in mEpiSCs, we compared the expression of pluripotency-related genes in mEpiSCs and mouse embryonic stem cells (mESCs) after either Cdh2 knockdown or Cdh2 over-expression. Introduction of specific siRNA against Cdh2 led to attenuation of pluripotency-related genes. Pluripotent gene expression was not recovered by over-expression of Cdh1 following Cdh2 knockdown. Western blot analysis and co-immunoprecipitation assays revealed that Cdh2 stabilizes FGFR1 in mEpiSCs. Furthermore, stable transfection of mESCs with Cdh2 cDNA followed by FGF2 supplementation accelerated cell differentiation. Thus, Cdh2 contributes to the establishment and maintenance of FGF signaling-dependent self-renewal in mEpiSCs through stabilization of FGFR1.

Basic Information on CDH1

Ligand Name: cadherin 1

Other Symbols: UVO, uvomorulin, CD324

Ligand Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CDH1

GeneCards: CDH1

HGNC Gene Group: Cadherins, CD molecules

Functional Annotations for CDH1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CDH1

CDH1 — ITGAE ・ CDH1 — ITGB7 ・ CDH1 — KLRG1 ・ CDH1 — CDH1 ・ CDH1 — ITGA2 ・ CDH1 — ITGB1 ・ CDH1 — PTPRJ

Basic Information on FGFR1

Receptor Name: fibroblast growth factor receptor 1

Other Symbols: FLT2, KAL2, H2, H3, H4, H5, CEK, FLG, BFGFR, N-SAM, CD331

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: FGFR1

GeneCards: FGFR1

HGNC Gene Group: Receptor kinases, CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for FGFR1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for FGFR1

FGF10 — FGFR1 ・ FGF16 — FGFR1 ・ FGF17 — FGFR1 ・ FGF18 — FGFR1 ・ FGF19 — FGFR1 ・ FGF1 — FGFR1 ・ FGF23 — FGFR1 ・ FGF2 — FGFR1 ・ FGF3 — FGFR1 ・ FGF4 — FGFR1 ・ FGF5 — FGFR1 ・ FGF6 — FGFR1 ・ FGF7 — FGFR1 ・ FGF8 — FGFR1 ・ FGF9 — FGFR1 ・ ANOS1 — FGFR1 ・ NCAM1 — FGFR1 ・ FGF20 — FGFR1 ・ FGF22 — FGFR1 ・ CCN2 — FGFR1 ・ FAM3B — FGFR1 ・ FGF21 — FGFR1 ・ GREM1 — FGFR1 ・ L1CAM — FGFR1 ・ MMP2 — FGFR1 ・ NECTIN1 — FGFR1 ・ PF4 — FGFR1