CDB25:0003501 EDIL3 — ITGB2

Experimentally validated in Human, Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep, Mouse

Title

Journal:; Year Published:

Abstract

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss.

Nature immunology, 2012; PubMed, Homo sapiens EDIL3 — Homo sapiens ITGB2

ABSTRACT: Aging is linked to greater susceptibility to chronic inflammatory diseases, several of which, including periodontitis, involve neutrophil-mediated tissue injury. Here we found that aging-associated periodontitis was accompanied by lower expression of Del-1, an endogenous inhibitor of neutrophil adhesion dependent on the integrin LFA-1, and by reciprocal higher expression of interleukin 17 (IL-17). Consistent with that, IL-17 inhibited gingival endothelial cell expression of Del-1, thereby promoting LFA-1-dependent recruitment of neutrophils. Young Del-1-deficient mice developed spontaneous periodontitis that featured excessive neutrophil infiltration and IL-17 expression; disease was prevented in mice doubly deficient in Del-1 and LFA-1 or in Del-1 and the IL-17 receptor. Locally administered Del-1 inhibited IL-17 production, neutrophil accumulation and bone loss. Therefore, Del-1 suppressed LFA-1-dependent recruitment of neutrophils and IL-17-triggered inflammatory pathology and may thus be a promising therapeutic agent for inflammatory diseases.

Basic Information on EDIL3

Ligand Name: EGF like repeats and discoidin domains 3

Other Symbols: DEL1

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: EDIL3

GeneCards: EDIL3

HGNC Gene Group: unknown

Functional Annotations for EDIL3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for EDIL3

EDIL3 — ITGAV ・ EDIL3 — ITGB3 ・ EDIL3 — ITGAL

Basic Information on ITGB2

Receptor Name: integrin subunit beta 2

Other Symbols: CD18, MFI7, LFA-1, MAC-1

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: ITGB2

GeneCards: ITGB2

HGNC Gene Group: CD molecules, Complement system, Integrins

Functional Annotations for ITGB2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGB2

C3 — ITGB2 ・ CD40LG — ITGB2 ・ CCN2 — ITGB2 ・ CCN1 — ITGB2 ・ F10 — ITGB2 ・ FGA — ITGB2 ・ FGG — ITGB2 ・ HP — ITGB2 ・ ICAM1 — ITGB2 ・ ICAM2 — ITGB2 ・ ICAM3 — ITGB2 ・ ICAM4 — ITGB2 ・ ICAM5 — ITGB2 ・ KNG1 — ITGB2 ・ LPA — ITGB2 ・ SPON2 — ITGB2 ・ VCAM1 — ITGB2 ・ CFH — ITGB2 ・ F11R — ITGB2 ・ FCER2 — ITGB2 ・ GP1BA — ITGB2 ・ ISG15 — ITGB2 ・ JAM3 — ITGB2 ・ PTN — ITGB2 ・ THY1 — ITGB2