CDB25:0003502 EFNA1 — EPHA10

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis.

Biochimica et biophysica acta, 2005; PubMed, Homo sapiens EFNA1 — Homo sapiens EPHA10

ABSTRACT: In mammals, 14 members of the Eph receptor tyrosine kinase family have been described so far. Here we present a not yet described member of this family denoted EphA10. We report the identification of three putative EphA10 isoforms: one soluble and two transmembrane isoforms. One of the latter isoforms lacked the sterile alpha motif commonly found in Eph receptors. The gene encoding EphA10 is located on chromosome 1p34 and expression studies show that EphA10 mRNA is mainly expressed in testis. Binding studies to ephrin ligands suggests that this receptor belongs to the EphA subclass of Eph receptors binding mainly to ephrin-A ligands.

Basic Information on EFNA1

Ligand Name: ephrin A1

Other Symbols: TNFAIP4, EPLG1, LERK1, ECKLG, GMAN

Ligand Location: secreted based on uniprot, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: EFNA1

GeneCards: EFNA1

HGNC Gene Group: Cupredoxin superfamily, Receptor ligands: Ephrins

Functional Annotations for EFNA1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for EFNA1

EFNA1 — EPHA1 ・ EFNA1 — EPHA2 ・ EFNA1 — EPHA3 ・ EFNA1 — EPHA4 ・ EFNA1 — EPHA5 ・ EFNA1 — EPHA6 ・ EFNA1 — EPHA7 ・ EFNA1 — EPHA8 ・ EFNA1 — EPHB2

Basic Information on EPHA10

Receptor Name: EPH receptor A10

Other Symbols: FLJ16103, FLJ33655

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: EPHA10

GeneCards: EPHA10

HGNC Gene Group: Receptor kinases, Fibronectin type III domain containing, Sterile alpha motif domain containing

Functional Annotations for EPHA10

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for EPHA10

EFNA2 — EPHA10 ・ EFNA3 — EPHA10 ・ EFNA4 — EPHA10 ・ EFNA5 — EPHA10