CDB15:0000647 FGG — ITGB2

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Dissection of the hyperadhesive phenotype of airway eosinophils in asthma.

American journal of respiratory cell and molecular biology, 2006; PubMed, Homo sapiens FGG — Homo sapiens ITGB2

ABSTRACT: Asthma is characterized by appearance of eosinophils in the airway. Eosinophils purified from the airway 48 h after segmental antigen challenge are described as exhibiting greater adhesion to albumin-coated surfaces via an unidentified beta2 integrin and increased expression of alphaMbeta2 (CD11b/18) compared with purified blood eosinophils. We have investigated the determinants of this hyperadhesive phenotype. Airway eosinophils exhibited increased reactivity with the CBRM1/5 anti-alphaM activation-sensitive antibody as well as enhanced adhesion to VCAM-1 (CD106) and diverse ligands, including albumin, ICAM-1 (CD54), fibrinogen, and vitronectin. Purified blood eosinophils did not adhere to the latter diverse ligands. Enhanced adhesion of airway eosinophils was blocked by anti-alphaMbeta2. Podosomes, structures implicated in cell movement and proteolysis of matrix proteins, were larger and more common on airway eosinophils adherent to VCAM-1 when compared with blood eosinophils. Incubation of blood eosinophils with IL-5 replicated the phenotype of airway eosinophils. That is, IL-5 enhanced recognition of alphaM by CBRM1/5; stimulated alphaMbeta2-mediated adhesion to VCAM-1, albumin, ICAM-1, fibrinogen, and vitronectin; and increased podosome formation on VCAM-1. Thus, the hyperadhesion of airway eosinophils after antigen challenge is mediated by upregulated and activated alphaMbeta2.

Basic Information on FGG

Ligand Name: fibrinogen gamma chain

Other Symbols: N/A

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: FGG

GeneCards: FGG

HGNC Gene Group: Receptor ligands, Fibrinogen C domain containing

Functional Annotations for FGG

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for FGG

FGG — ITGA2B ・ FGG — ITGAV ・ FGG — TLR4 ・ FGG — ITGAM ・ FGG — ITGB3

Basic Information on ITGB2

Receptor Name: integrin subunit beta 2

Other Symbols: CD18, MFI7, LFA-1, MAC-1

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: ITGB2

GeneCards: ITGB2

HGNC Gene Group: CD molecules, Complement system, Integrins

Functional Annotations for ITGB2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGB2

C3 — ITGB2 ・ CD40LG — ITGB2 ・ CCN2 — ITGB2 ・ CCN1 — ITGB2 ・ F10 — ITGB2 ・ FGA — ITGB2 ・ HP — ITGB2 ・ ICAM1 — ITGB2 ・ ICAM2 — ITGB2 ・ ICAM3 — ITGB2 ・ ICAM4 — ITGB2 ・ ICAM5 — ITGB2 ・ KNG1 — ITGB2 ・ LPA — ITGB2 ・ SPON2 — ITGB2 ・ VCAM1 — ITGB2 ・ CFH — ITGB2 ・ EDIL3 — ITGB2 ・ F11R — ITGB2 ・ FCER2 — ITGB2 ・ GP1BA — ITGB2 ・ ISG15 — ITGB2 ・ JAM3 — ITGB2 ・ PTN — ITGB2 ・ THY1 — ITGB2