CDB25:0003424 COMP — CD36

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways.

Journal of experimental & clinical cancer research : CR, 2018; PubMed, Homo sapiens COMP — Homo sapiens CD36

ABSTRACT: Cartilage oligomeric matrix protein (COMP) is known to promote fibrosis in skin, lung and liver. Emerging evidence shows that COMP plays critical roles in tumor development, including breast cancer, colon cancer and hepatocellular carcinoma (HCC). Nevertheless, the role of COMP in HCC proliferation and metastasis and its underlying mechanisms remain fully unclear.

Basic Information on COMP

Ligand Name: cartilage oligomeric matrix protein

Other Symbols: PSACH, EDM1, EPD1, MED, THBS5, TSP5, TSP-5

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: COMP

GeneCards: COMP

HGNC Gene Group: Thrombospondin family

Functional Annotations for COMP

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for COMP

COMP — CD47 ・ COMP — ITGB3 ・ COMP — ITGA7 ・ COMP — ITGAV ・ COMP — NOTCH1

Basic Information on CD36

Receptor Name: CD36 molecule (CD36 blood group)

Other Symbols: SCARB3, GPIV, FAT, GP4, GP3B, GPIIIB

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CD36

GeneCards: CD36

HGNC Gene Group: Scavenger receptors, Blood group antigens, CD molecules

Functional Annotations for CD36

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD36

THBS1 — CD36 ・ SAA1 — CD36 ・ ADAMTS13 — CD36 ・ LY6H — CD36 ・ NRN1 — CD36 ・ S100A12 — CD36 ・ S100A8 — CD36 ・ S100A9 — CD36 ・ SCRG1 — CD36 ・ THBS2 — CD36 ・ VWC2L — CD36