CDB25:0003425 COMP — ITGA7

Experimentally validated in Rat; Orthology-inferred in Human, Mouse, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin.

Circulation research, 2010; PubMed, Rattus norvegicus Comp — Rattus norvegicus Itga7

ABSTRACT: Vascular smooth muscle cells (VSMCs) switching from a contractile/differentiated to a synthetic/dedifferentiated phenotype has an essential role in atherosclerosis, postangioplastic restenosis and hypertension. However, how normal VSMCs maintain the differentiated state is less understood.

Basic Information on COMP

Ligand Name: cartilage oligomeric matrix protein

Other Symbols: PSACH, EDM1, EPD1, MED, THBS5, TSP5, TSP-5

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: COMP

GeneCards: COMP

HGNC Gene Group: Thrombospondin family

Functional Annotations for COMP

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for COMP

COMP — CD47 ・ COMP — ITGB3 ・ COMP — CD36 ・ COMP — ITGAV ・ COMP — NOTCH1

Basic Information on ITGA7

Receptor Name: integrin subunit alpha 7

Other Symbols: N/A

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: ITGA7

GeneCards: ITGA7

HGNC Gene Group: Integrins

Functional Annotations for ITGA7

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGA7

LAMA1 — ITGA7 ・ LAMA2 — ITGA7 ・ LAMB1 — ITGA7 ・ LAMC1 — ITGA7 ・ TNC — ITGA7 ・ LAMA5 — ITGA7 ・ LAMB2 — ITGA7 ・ TIMP3 — ITGA7