CDB25:0003070 ADAMTS13 — CD36

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

ADAMTS13 binds to CD36: a potential mechanism for platelet and endothelial localization of ADAMTS13.

Transfusion, 2009; PubMed, Homo sapiens ADAMTS13 — Homo sapiens CD36

ABSTRACT: ADAMTS13 cleaves ultralarge von Willebrand factor (VWF) and plays a significant role in vascular biology and thrombotic thrombocytopenic purpura. CD36, a transmembrane protein present on endothelial cells and platelets (PLTs), binds to thrombospondin via three thrombospondin type 1 repeats. ADAMTS13 contains eight thrombospondin type 1 repeats.

Basic Information on ADAMTS13

Ligand Name: ADAM metallopeptidase with thrombospondin type 1 motif 13

Other Symbols: C9orf8, VWFCP, TTP, vWF-CP, FLJ42993, MGC118899, MGC118900, DKFZp434C2322

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: ADAMTS13

GeneCards: ADAMTS13

HGNC Gene Group: Metallopeptidases

Functional Annotations for ADAMTS13

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for ADAMTS13

ADAMTS13 — CD163

Basic Information on CD36

Receptor Name: CD36 molecule (CD36 blood group)

Other Symbols: SCARB3, GPIV, FAT, GP4, GP3B, GPIIIB

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CD36

GeneCards: CD36

HGNC Gene Group: Scavenger receptors, Blood group antigens, CD molecules

Functional Annotations for CD36

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD36

THBS1 — CD36 ・ SAA1 — CD36 ・ COMP — CD36 ・ LY6H — CD36 ・ NRN1 — CD36 ・ S100A12 — CD36 ・ S100A8 — CD36 ・ S100A9 — CD36 ・ SCRG1 — CD36 ・ THBS2 — CD36 ・ VWC2L — CD36