CDB25:0003268 CCN2 — TGFBR1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Single-cell tumor heterogeneity landscape of hepatocellular carcinoma: unraveling the pro-metastatic subtype and its interaction loop with fibroblasts.

Molecular cancer, 2024; PubMed, Homo sapiens CCN2 — Homo sapiens TGFBR1

ABSTRACT: Tumor heterogeneity presents a formidable challenge in understanding the mechanisms driving tumor progression and metastasis. The heterogeneity of hepatocellular carcinoma (HCC) in cellular level is not clear.

Basic Information on CCN2

Ligand Name: cellular communication network factor 2

Other Symbols: CTGF, IGFBP8

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CCN2

GeneCards: CCN2

HGNC Gene Group: Cellular communication network factors

Functional Annotations for CCN2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CCN2

CCN2 — ITGA5 ・ CCN2 — ITGAM ・ CCN2 — ITGB2 ・ CCN2 — LRP1 ・ CCN2 — LRP6 ・ CCN2 — NTRK1 ・ CCN2 — FGFR2 ・ CCN2 — IGF2R ・ CCN2 — EGFR ・ CCN2 — FGFR1 ・ CCN2 — FGFR3 ・ CCN2 — ITGB1

Basic Information on TGFBR1

Receptor Name: transforming growth factor beta receptor 1

Other Symbols: MSSE, ESS1, ALK-5, ACVRLK4, ALK5, TBRI, TBR-i

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: TGFBR1

GeneCards: TGFBR1

HGNC Gene Group: Receptor kinases

Functional Annotations for TGFBR1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TGFBR1

GDF9 — TGFBR1 ・ TGFB1 — TGFBR1 ・ TGFB3 — TGFBR1 ・ BMP8A — TGFBR1 ・ CRIPTO — TGFBR1 ・ GDF10 — TGFBR1 ・ GDF11 — TGFBR1 ・ MSTN — TGFBR1 ・ THBS1 — TGFBR1