CDB25:0003266 CCN2 — FGFR3

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its signaling.

FEBS letters, 2012; PubMed, Homo sapiens CCN2 — Homo sapiens FGFR3

ABSTRACT: CCN2 plays a critical role in the development of mesenchymal tissues such as cartilage and bone, and the binding of CCN2 to various cytokines and receptors regulates their signaling.By screening a protein array, we found that CCN2 could bind to fibroblast growth factor receptors (FGFRs) 2 and 3, with a higher affinity toward FGFR2.We ascertained that FGFR2 bound to CCN2 and that the binding of FGFR2 to FGF2 and FGF4 was enhanced by CCN2.CCN2 and FGF2 had a collaborative effect on the phosphorylation of ERK and the differentiation of osteoblastic cells.The present results indicate the biological significance of the binding of CCN2 to FGFR2 in bone metabolism.

Basic Information on CCN2

Ligand Name: cellular communication network factor 2

Other Symbols: CTGF, IGFBP8

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CCN2

GeneCards: CCN2

HGNC Gene Group: Cellular communication network factors

Functional Annotations for CCN2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CCN2

CCN2 — ITGA5 ・ CCN2 — ITGAM ・ CCN2 — ITGB2 ・ CCN2 — LRP1 ・ CCN2 — LRP6 ・ CCN2 — NTRK1 ・ CCN2 — FGFR2 ・ CCN2 — IGF2R ・ CCN2 — EGFR ・ CCN2 — FGFR1 ・ CCN2 — ITGB1 ・ CCN2 — TGFBR1

Basic Information on FGFR3

Receptor Name: fibroblast growth factor receptor 3

Other Symbols: ACH, CEK2, JTK4, CD333

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: FGFR3

GeneCards: FGFR3

HGNC Gene Group: Receptor kinases, CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for FGFR3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for FGFR3

FGF16 — FGFR3 ・ FGF17 — FGFR3 ・ FGF18 — FGFR3 ・ FGF19 — FGFR3 ・ FGF1 — FGFR3 ・ FGF23 — FGFR3 ・ FGF2 — FGFR3 ・ FGF4 — FGFR3 ・ FGF5 — FGFR3 ・ FGF6 — FGFR3 ・ FGF8 — FGFR3 ・ FGF9 — FGFR3 ・ BGN — FGFR3 ・ FGF20 — FGFR3 ・ FAM3B — FGFR3 ・ FGF21 — FGFR3