CDB25:0003260 CCL8 — CCR8

Experimentally validated in Mixed species, Mouse; Orthology-inferred in Human, Frog, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Sheep, Mouse

Title

Journal:; Year Published:

Abstract

Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.

Nature immunology, 2011; PubMed, Mus Musculus Ccl8 — Homo sapiens CCR8

ABSTRACT: Mouse CCL8 is a CC chemokine of the monocyte chemoattractant protein (MCP) family whose biological activity and receptor usage have remained elusive. Here we show that CCL8 is highly expressed in the skin, where it serves as an agonist for the chemokine receptor CCR8 but not for CCR2. This distinguishes CCL8 from all other MCP chemokines. CCL8 responsiveness defined a population of highly differentiated, CCR8-expressing inflammatory T helper type 2 (T(H)2) cells enriched for interleukin (IL)-5. Ccr8- and Ccl8-deficient mice had markedly less eosinophilic inflammation than wild-type or Ccr4-deficient mice in a model of chronic atopic dermatitis. Adoptive transfer studies established CCR8 as a key regulator of T(H)2 cell recruitment into allergen-inflamed skin. In humans, CCR8 expression also defined an IL-5-enriched T(H)2 cell subset. The CCL8-CCR8 chemokine axis is therefore a crucial regulator of T(H)2 cell homing that drives IL-5-mediated chronic allergic inflammation.

Basic Information on CCL8

Ligand Name: C-C motif chemokine ligand 8

Other Symbols: SCYA8, MCP-2, HC14

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: CCL8

GeneCards: CCL8

HGNC Gene Group: Receptor ligands: Chemokine ligands

Functional Annotations for CCL8

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CCL8

CCL8 — ACKR2 ・ CCL8 — ACKR4 ・ CCL8 — CCR1 ・ CCL8 — CCR2 ・ CCL8 — CCR3 ・ CCL8 — CCR5 ・ CCL8 — ACKR1

Basic Information on CCR8

Receptor Name: C-C motif chemokine receptor 8

Other Symbols: CMKBRL2, CMKBR8, CY6, TER1, CKR-L1, GPR-CY6, CDw198

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CCR8

GeneCards: CCR8

HGNC Gene Group: 7TM proteins, CD molecules

Functional Annotations for CCR8

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CCR8

CCL16 — CCR8 ・ CCL17 — CCR8 ・ CCL1 — CCR8 ・ CCL4 — CCR8 ・ CCL18 — CCR8