CDB15:0000203 CCL16 — CCR8

Experimentally validated in Human; Orthology-inferred in Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Sheep

Title

Journal:; Year Published:

Abstract

LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.

Blood, 2000; PubMed, Homo sapiens CCL16 — Homo sapiens CCR8

ABSTRACT: Liver-expressed chemokine (LEC) is an unusually large CC chemokine, which is also known as LMC, HCC-4, NCC-4, and CCL16. Previously, LEC was shown to induce leukocyte migration but the responsible signaling receptors were not characterized. We report chemotaxis and competitive binding studies that show LEC binds to and activates CCR1 and CCR8 transfected HEK-293 cells. LEC induced maximal migration of CCR1 and CCR8 transfected cells at 89.3 nmol/L and cell adhesion at 5.6 nmol/L. The molar concentration of LEC required to induce maximum cell migration is 20- to 200-fold greater than that required for RANTES or I309, respectively. All 3 chemokines induced maximal static adhesion at 5 to 7 nmol/L. A neutralizing polyclonal antibody to LEC was developed to demonstrate that the unusually high concentration of LEC required to induce chemotaxis was a property of LEC and not as a result of an irrelevant protein contamination. This study suggests that LEC may be a more effective inducer of cell adhesion than cell migration.

Basic Information on CCL16

Ligand Name: C-C motif chemokine ligand 16

Other Symbols: SCYA16, NCC-4, SCYL4, LEC, HCC-4, LMC, LCC-1, CKb12, Mtn-1

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: CCL16

GeneCards: CCL16

HGNC Gene Group: Receptor ligands: Chemokine ligands

Functional Annotations for CCL16

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CCL16

CCL16 — CCR1 ・ CCL16 — CCR2 ・ CCL16 — CCR5 ・ CCL16 — HRH4 ・ CCL16 — ACKR1

Basic Information on CCR8

Receptor Name: C-C motif chemokine receptor 8

Other Symbols: CMKBRL2, CMKBR8, CY6, TER1, CKR-L1, GPR-CY6, CDw198

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CCR8

GeneCards: CCR8

HGNC Gene Group: 7TM proteins, CD molecules

Functional Annotations for CCR8

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CCR8

CCL17 — CCR8 ・ CCL1 — CCR8 ・ CCL4 — CCR8 ・ CCL18 — CCR8 ・ CCL8 — CCR8