CDB15:0000278 CCL8 — ACKR1

Experimentally validated in Human; Orthology-inferred in Mouse, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The human Duffy antigen binds selected inflammatory but not homeostatic chemokines.

Biochemical and biophysical research communications, 2004; PubMed, Homo sapiens CCL8 — Homo sapiens ACKR1

ABSTRACT: The aim of the study was to compare the ability of the human Duffy antigen to bind homeostatic and inflammatory chemokines. Homeostatic chemokines did not bind to the Duffy antigen on erythrocytes with high affinity. In contrast, 60% of inflammatory chemokines bound strongly to Duffy, with no obvious preference for CXC or CC classes. It was investigated if this binding profile was reflected in the binding pattern of endothelial cells. Two examples of homeostatic (125I-CXCL12 and 125I-CCL21) and inflammatory (125I-CXCL8 and 125I-CCL5) chemokines were incubated with human synovia. In agreement with the erythrocyte binding data, intense specific signals for CXCL8 and CCL5 binding were found on endothelial cells, whereas CXCL12 and CCL21 showed only weak binding to these cells. Our study provides evidence that the human Duffy antigen binds selected inflammatory, but not homeostatic, chemokines and that this binding pattern is reflected by endothelial cells within inflamed and non-inflamed tissue.

Basic Information on CCL8

Ligand Name: C-C motif chemokine ligand 8

Other Symbols: SCYA8, MCP-2, HC14

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: CCL8

GeneCards: CCL8

HGNC Gene Group: Receptor ligands: Chemokine ligands

Functional Annotations for CCL8

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CCL8

CCL8 — ACKR2 ・ CCL8 — ACKR4 ・ CCL8 — CCR1 ・ CCL8 — CCR2 ・ CCL8 — CCR3 ・ CCL8 — CCR5 ・ CCL8 — CCR8

Basic Information on ACKR1

Receptor Name: atypical chemokine receptor 1 (Duffy blood group)

Other Symbols: FY, DARC, CCBP1, GPD, Dfy, CD234

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: ACKR1

GeneCards: ACKR1

HGNC Gene Group: 7TM proteins, Blood group antigens, CD molecules

Functional Annotations for ACKR1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ACKR1

CCL17 — ACKR1 ・ CCL2 — ACKR1 ・ CCL5 — ACKR1 ・ CCL7 — ACKR1 ・ CXCL1 — ACKR1 ・ CXCL5 — ACKR1 ・ CXCL8 — ACKR1 ・ CCL1 — ACKR1 ・ CCL11 — ACKR1 ・ CCL13 — ACKR1 ・ CCL14 — ACKR1 ・ CCL16 — ACKR1 ・ CCL18 — ACKR1 ・ CXCL10 — ACKR1 ・ CXCL11 — ACKR1 ・ CXCL12 — ACKR1 ・ CXCL13 — ACKR1 ・ CXCL2 — ACKR1 ・ CXCL6 — ACKR1 ・ CXCL9 — ACKR1