CDB25:0004451 VWF — SCARA5

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen.

Journal of thrombosis and haemostasis : JTH, 2019; PubMed, Homo sapiens VWF — Homo sapiens SCARA5

ABSTRACT: Scavenger receptors play a significant role in clearing aged proteins from the plasma, including the large glycoprotein coagulation factors von Willebrand factor (VWF) and factor VIII (FVIII). A large genome-wide association study meta-analysis has identified genetic variants in the gene SCARA5, which encodes the class A scavenger receptor SCARA5, as being associated with plasma levels of VWF and FVIII.

Basic Information on VWF

Ligand Name: von Willebrand factor

Other Symbols: F8VWF

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: VWF

GeneCards: VWF

HGNC Gene Group: Receptor ligands

Functional Annotations for VWF

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for VWF

VWF — GP1BA ・ VWF — ITGA2B ・ VWF — SELP ・ VWF — CLEC4M ・ VWF — GP9 ・ VWF — ITGA4 ・ VWF — ITGA9 ・ VWF — ITGAV ・ VWF — ITGB1 ・ VWF — ITGB3 ・ VWF — LRP1 ・ VWF — STAB2

Basic Information on SCARA5

Receptor Name: scavenger receptor class A member 5

Other Symbols: FLJ23907, MGC45780, NET33

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: SCARA5

GeneCards: SCARA5

HGNC Gene Group: Scavenger receptors, Scavenger receptor cysteine rich domain containing, MicroRNA host genes

Functional Annotations for SCARA5

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for SCARA5

FTH1 — SCARA5 ・ FTL — SCARA5 ・ HMGB1 — SCARA5