CDB25:0004438 VEGFA — PTPRZ1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor.

Molecular cancer, 2015; PubMed, Homo sapiens VEGFA — Homo sapiens PTPRZ1

ABSTRACT: Receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN). RPTPβ/ζ interacts with ανβ₃ on the cell surface and upon binding of PTN leads to c-Src dephosphorylation at Tyr530, β₃ Tyr773 phosphorylation, cell surface nucleolin (NCL) localization and stimulation of cell migration. c-Src-mediated β₃ Tyr773 phosphorylation is also observed after vascular endothelial growth factor 165 (VEGF₁₆₅) stimulation of endothelial cells and is essential for VEGF receptor type 2 (VEGFR2) - ανβ₃ integrin association and subsequent signaling. In the present work, we studied whether RPTPβ/ζ mediates angiogenic actions of VEGF.

Basic Information on VEGFA

Ligand Name: vascular endothelial growth factor A

Other Symbols: VEGF, VEGF-A, VPF

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: VEGFA

GeneCards: VEGFA

HGNC Gene Group: Receptor ligands: VEGF family

Functional Annotations for VEGFA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for VEGFA

VEGFA — FLT1 ・ VEGFA — GPC1 ・ VEGFA — ITGA9 ・ VEGFA — ITGB1 ・ VEGFA — KDR ・ VEGFA — NRP1 ・ VEGFA — NRP2 ・ VEGFA — CD44 ・ VEGFA — PDGFRB

Basic Information on PTPRZ1

Receptor Name: protein tyrosine phosphatase receptor type Z1

Other Symbols: PTPZ, PTPRZ, PTP18, RPTPB, phosphacan

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: PTPRZ1

GeneCards: PTPRZ1

HGNC Gene Group: Phosphatases, Fibronectin type III domain containing

Functional Annotations for PTPRZ1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for PTPRZ1

MDK — PTPRZ1 ・ PTN — PTPRZ1 ・ TNC — PTPRZ1 ・ CNTN1 — PTPRZ1 ・ IL34 — PTPRZ1 ・ TNR — PTPRZ1