CDB15:0001487 TNC — ITGA9

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Tenascin-C Promotes Tumor Cell Migration and Metastasis through Integrin α9β1-Mediated YAP Inhibition.

Cancer research, 2018; PubMed, Homo sapiens TNC — Homo sapiens ITGA9

ABSTRACT: Tenascin-C is an extracellular matrix molecule that drives progression of many types of human cancer, but the basis for its actions remains obscure. In this study, we describe a cell-autonomous signaling mechanism explaining how tenascin-C promotes cancer cell migration in the tumor microenvironment. In a murine xenograft model of advanced human osteosarcoma, tenascin-C and its receptor integrin α9β1 were determined to be essential for lung metastasis of tumor cells. We determined that activation of this pathway also reduced tumor cell-autonomous expression of target genes for the transcription factor YAP. In clinical specimens, a genetic signature comprising four YAP target genes represents prognostic impact. Taken together, our results illuminate how tumor cell deposition of tenascin-C in the tumor microenvironment promotes invasive migration and metastatic progression.

Basic Information on TNC

Ligand Name: tenascin C

Other Symbols: HXB, DFNA56, TN, MGC167029

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: TNC

GeneCards: TNC

HGNC Gene Group: Fibrinogen C domain containing, Fibronectin type III domain containing

Functional Annotations for TNC

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for TNC

TNC — CNTN1 ・ TNC — EGFR ・ TNC — ITGA2 ・ TNC — ITGA7 ・ TNC — ITGA8 ・ TNC — ITGAV ・ TNC — ITGB1 ・ TNC — PTPRB ・ TNC — PTPRZ1 ・ TNC — ITGB3 ・ TNC — CNTN2 ・ TNC — FN1 ・ TNC — ITGB6 ・ TNC — TLR4

Basic Information on ITGA9

Receptor Name: integrin subunit alpha 9

Other Symbols: RLC, ITGA4L, ALPHA-RLC

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: ITGA9

GeneCards: ITGA9

HGNC Gene Group: Integrins

Functional Annotations for ITGA9

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGA9

ADAM12 — ITGA9 ・ ADAM15 — ITGA9 ・ ADAM2 — ITGA9 ・ F13A1 — ITGA9 ・ VEGFD — ITGA9 ・ FN1 — ITGA9 ・ PLG — ITGA9 ・ SPP1 — ITGA9 ・ TGM2 — ITGA9 ・ VCAM1 — ITGA9 ・ VEGFA — ITGA9 ・ VEGFC — ITGA9 ・ L1CAM — ITGA9 ・ PLAUR — ITGA9 ・ SVEP1 — ITGA9 ・ VWF — ITGA9