CDB15:0000018 ADAM2 — ITGA9

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

ADAM2 interactions with mouse eggs and cell lines expressing α4/α9 (ITGA4/ITGA9) integrins: implications for integrin-based adhesion and fertilization.

PloS one, 2010; PubMed, Mus Musculus Adam2 — Homo sapiens ITGA9

ABSTRACT: Integrins are heterodimeric cell adhesion molecules, with 18 α (ITGA) and eight β (ITGB) subunits forming 24 heterodimers classified into five families. Certain integrins, especially the α(4)/α(9) (ITGA4/ITGA9) family, interact with members of the ADAM (a disintegrin and metalloprotease) family. ADAM2 is among the better characterized and also of interest because of its role in sperm function. Having shown that ITGA9 on mouse eggs participates in mouse sperm-egg interactions, we sought to characterize ITGA4/ITGA9-ADAM2 interactions.

Basic Information on ADAM2

Ligand Name: ADAM metallopeptidase domain 2

Other Symbols: FTNB, PH-30b, PH30, CT15

Ligand Location: cell membrane based on perplexity

HGNC Gene Symbol Report: ADAM2

GeneCards: ADAM2

HGNC Gene Group: Metallopeptidases

Functional Annotations for ADAM2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for ADAM2

ADAM2 — CD9 ・ ADAM2 — ITGA6 ・ ADAM2 — ITGB1 ・ ADAM2 — ITGB7 ・ ADAM2 — ITGA4

Basic Information on ITGA9

Receptor Name: integrin subunit alpha 9

Other Symbols: RLC, ITGA4L, ALPHA-RLC

Receptor Location: cell membrane based on hpa, perplexity

HGNC Gene Symbol Report: ITGA9

GeneCards: ITGA9

HGNC Gene Group: Integrins

Functional Annotations for ITGA9

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGA9

ADAM12 — ITGA9 ・ ADAM15 — ITGA9 ・ F13A1 — ITGA9 ・ VEGFD — ITGA9 ・ FN1 — ITGA9 ・ PLG — ITGA9 ・ SPP1 — ITGA9 ・ TGM2 — ITGA9 ・ TNC — ITGA9 ・ VCAM1 — ITGA9 ・ VEGFA — ITGA9 ・ VEGFC — ITGA9 ・ L1CAM — ITGA9 ・ PLAUR — ITGA9 ・ SVEP1 — ITGA9 ・ VWF — ITGA9