CDB25:0004396 TIMP2 — MMP14

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset

Title

Journal:; Year Published:

Abstract

MMP-14 and TIMP-2 overexpression protects against hydroquinone-induced oxidant injury in RPE: implications for extracellular matrix turnover.

Investigative ophthalmology & visual science, 2007; PubMed, Homo sapiens TIMP2 — Homo sapiens MMP14

ABSTRACT: To investigate whether overexpression of MMP-14 and/or TIMP-2 would overcome the effect of nonlethal oxidant injury with hydroquinone (HQ) on MMP-2 activity.

Basic Information on TIMP2

Ligand Name: TIMP metallopeptidase inhibitor 2

Other Symbols: CSC-21K

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: TIMP2

GeneCards: TIMP2

HGNC Gene Group: Tissue inhibitor of metallopeptidases

Functional Annotations for TIMP2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for TIMP2

TIMP2 — ITGA3 ・ TIMP2 — ITGB1 ・ TIMP2 — MMP2

Basic Information on MMP14

Receptor Name: matrix metallopeptidase 14

Other Symbols: MT1-MMP

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: MMP14

GeneCards: MMP14

HGNC Gene Group: Metallopeptidases

Functional Annotations for MMP14

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for MMP14

LUM — MMP14