CDB25:0003936 LUM — MMP14

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Lumican: a new inhibitor of matrix metalloproteinase-14 activity.

FEBS letters, 2014; PubMed, Homo sapiens LUM — Homo sapiens MMP14

ABSTRACT: We previously showed that lumican regulates MMP-14 expression. The aim of this study was to compare the effect of lumican and decorin on MMP-14 activity. In contrast to decorin, the glycosylated form of lumican was able to significantly decrease MMP-14 activity in B16F1 melanoma cells. Our results suggest that a direct interaction occurs between lumican and MMP-14. Lumican behaves as a competitive inhibitor which leads to a complete blocking of the activity of MMP-14. It binds to the catalytic domain of MMP-14 with moderate affinity (KD∼275 nM). Lumican may protect collagen against MMP-14 proteolysis, thus influencing cell-matrix interaction in tumor progression.

Basic Information on LUM

Ligand Name: lumican

Other Symbols: LDC, SLRR2D

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: LUM

GeneCards: LUM

HGNC Gene Group: Proteoglycans

Functional Annotations for LUM

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LUM

Basic Information on MMP14

Receptor Name: matrix metallopeptidase 14

Other Symbols: MT1-MMP

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: MMP14

GeneCards: MMP14

HGNC Gene Group: Metallopeptidases

Functional Annotations for MMP14

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for MMP14

TIMP2 — MMP14