CDB20:0002948 TFF3 — CXCR4

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

CXCR4 and CXCR7 Mediate TFF3-Induced Cell Migration Independently From the ERK1/2 Signaling Pathway.

Investigative ophthalmology & visual science, 2016; PubMed, Homo sapiens TFF3 — Homo sapiens CXCR4

ABSTRACT: Trefoil factor family (TFF) peptides, and in particular TFF3, are characteristic secretory products of mucous epithelia that promote antiapoptosis, epithelial migration, restitution, and wound healing. For a long time, a receptor for TFF3 had not yet been identified. However, the chemokine receptor CXCR4 has been described as a low affinity receptor for TFF2. Additionally, CXCR7, which is able to heterodimerize with CXCR4, has also been discussed as a potential TFF2 receptor. Since there are distinct structural similarities between the three known TFF peptides, this study evaluated whether CXCR4 and CXCR7 may also act as putative TFF3 receptors.

Basic Information on TFF3

Ligand Name: trefoil factor 3

Other Symbols: HITF, ITF

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: TFF3

GeneCards: TFF3

HGNC Gene Group: unknown

Functional Annotations for TFF3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for TFF3

TFF3 — ACKR3 ・ TFF3 — LINGO2

Basic Information on CXCR4

Receptor Name: C-X-C motif chemokine receptor 4

Other Symbols: LESTR, NPY3R, HM89, NPYY3R, D2S201E, fusin, HSY3RR, NPYR, CD184

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CXCR4

GeneCards: CXCR4

HGNC Gene Group: 7TM proteins, CD molecules

Functional Annotations for CXCR4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CXCR4

CEL — CXCR4 ・ CXCL12 — CXCR4 ・ ZG16B — CXCR4 ・ CXCL14 — CXCR4 ・ MIF — CXCR4 ・ TFF2 — CXCR4 ・ CXCL17 — CXCR4 ・ DEFB103A — CXCR4 ・ GPR15LG — CXCR4 ・ HMGB1 — CXCR4