CDB25:0003699 GPR15LG — CXCR4

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration.

Cell communication and signaling : CCS, 2025; PubMed, Homo sapiens GPR15LG — Homo sapiens CXCR4

ABSTRACT: GPR15LG, a chemokine-like ligand for the G-protein coupled receptor 15 (GPR15), is abundantly expressed in the gastrointestinal mucosa and inflamed skin. Emerging evidence suggests its involvement in inflammatory disorders and cancers. C-X-C chemokine receptor type 4 (CXCR4) plays a critical role in immune cell trafficking and cancer metastasis. Recent evidence suggests a connection between GPR15LG and CXCR4 signaling, which has not been investigated so far.

Basic Information on GPR15LG

Ligand Name: G protein-coupled receptor 15 ligand

Other Symbols: C10orf99, UNQ1833, RLLV1833, FLJ21763, CSBF, AP-57, GPR15L

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: GPR15LG

GeneCards: GPR15LG

HGNC Gene Group: unknown

Functional Annotations for GPR15LG

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for GPR15LG

GPR15LG — GPR15 ・ GPR15LG — SUSD2 ・ GPR15LG — ACKR5

Basic Information on CXCR4

Receptor Name: C-X-C motif chemokine receptor 4

Other Symbols: LESTR, NPY3R, HM89, NPYY3R, D2S201E, fusin, HSY3RR, NPYR, CD184

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CXCR4

GeneCards: CXCR4

HGNC Gene Group: 7TM proteins, CD molecules

Functional Annotations for CXCR4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CXCR4

CEL — CXCR4 ・ CXCL12 — CXCR4 ・ ZG16B — CXCR4 ・ CXCL14 — CXCR4 ・ MIF — CXCR4 ・ TFF2 — CXCR4 ・ TFF3 — CXCR4 ・ CXCL17 — CXCR4 ・ DEFB103A — CXCR4 ・ HMGB1 — CXCR4