CDB25:0004353 TENM3 — ADGRL1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Pooled extracellular receptor-ligand interaction screening using CRISPR activation.

Genome biology, 2018; PubMed, Homo sapiens TENM3 — Homo sapiens ADGRL1

ABSTRACT: Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for high-affinity antibodies and low-affinity ligands can be unambiguously identified when used in pools or as individual binding probes. We apply this technique to identify ligands for the adhesion G-protein-coupled receptors and show that the Nogo myelin-associated inhibitory proteins are ligands for ADGRB1. This method will enable extracellular receptor-ligand identification on a genome-wide scale.

Basic Information on TENM3

Ligand Name: teneurin transmembrane protein 3

Other Symbols: ODZ3, Ten-M3, KIAA1455, TEN3

Ligand Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: TENM3

GeneCards: TENM3

HGNC Gene Group: MicroRNA host genes, Teneurin transmembrane protein family

Functional Annotations for TENM3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for TENM3

Basic Information on ADGRL1

Receptor Name: adhesion G protein-coupled receptor L1

Other Symbols: LPHN1, KIAA0821, CIRL1, LEC2

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: ADGRL1

GeneCards: ADGRL1

HGNC Gene Group: 7TM proteins, Olfactomedin domain containing

Functional Annotations for ADGRL1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ADGRL1

FLRT1 — ADGRL1 ・ FLRT2 — ADGRL1 ・ FLRT3 — ADGRL1 ・ NRXN1 — ADGRL1 ・ TAFA2 — ADGRL1 ・ TENM2 — ADGRL1 ・ TENM4 — ADGRL1