CDB25:0004337 TAFA2 — ADGRL1

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway.

Life sciences, 2023; PubMed, Mus Musculus Tafa2 — Mus Musculus Adgrl1

ABSTRACT: TAFA2, a cytokine specifically expressed in the central nervous system, plays a vital role in neuronal cell survival. TAFA2 deficiency has been correlated to various neurological disorders in mice and humans. However, the underlying mechanism remains elusive, especially its membrane-binding receptor through which TAFA2 functions. This study aimed to identify the specific binding receptor responsible for the anti-apoptotic effects of TAFA2.

Basic Information on TAFA2

Ligand Name: TAFA chemokine like family member 2

Other Symbols: FAM19A2, TAFA-2

Ligand Location: secreted based on perplexity

HGNC Gene Symbol Report: TAFA2

GeneCards: TAFA2

HGNC Gene Group: TAFA chemokine like family

Functional Annotations for TAFA2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for TAFA2

TAFA2 — KIR2DL5A ・ TAFA2 — KIR3DL1 ・ TAFA2 — KIR3DL2 ・ TAFA2 — KIR3DL3 ・ TAFA2 — NRXN1 ・ TAFA2 — RNF167

Basic Information on ADGRL1

Receptor Name: adhesion G protein-coupled receptor L1

Other Symbols: LPHN1, KIAA0821, CIRL1, LEC2

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: ADGRL1

GeneCards: ADGRL1

HGNC Gene Group: 7TM proteins, Olfactomedin domain containing

Functional Annotations for ADGRL1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ADGRL1

FLRT1 — ADGRL1 ・ FLRT2 — ADGRL1 ・ FLRT3 — ADGRL1 ・ NRXN1 — ADGRL1 ・ TENM2 — ADGRL1 ・ TENM3 — ADGRL1 ・ TENM4 — ADGRL1