CDB15:0001395 SLIT2 — ROBO1

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.

Cell, 1999; PubMed, Homo sapiens SLIT2 — Rattus norvegicus Robo1

ABSTRACT: Extending axons in the developing nervous system are guided in part by repulsive cues. Genetic analysis in Drosophila, reported in a companion to this paper, identifies the Slit protein as a candidate ligand for the repulsive guidance receptor Roundabout (Robo). Here we describe the characterization of three mammalian Slit homologs and show that the Drosophila Slit protein and at least one of the mammalian Slit proteins, Slit2, are proteolytically processed and show specific, high-affinity binding to Robo proteins. Furthermore, recombinant Slit2 can repel embryonic spinal motor axons in cell culture. These results support the hypothesis that Slit proteins have an evolutionarily conserved role in axon guidance as repulsive ligands for Robo receptors.

Basic Information on SLIT2

Ligand Name: slit guidance ligand 2

Other Symbols: SLIL3, Slit-2

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: SLIT2

GeneCards: SLIT2

HGNC Gene Group: MicroRNA host genes

Functional Annotations for SLIT2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for SLIT2

SLIT2 — GPC1 ・ SLIT2 — ROBO2 ・ SLIT2 — ROBO4 ・ SLIT2 — APP ・ SLIT2 — LRP1 ・ SLIT2 — PLXNA1

Basic Information on ROBO1

Receptor Name: roundabout guidance receptor 1

Other Symbols: DUTT1, FLJ21882, SAX3

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: ROBO1

GeneCards: ROBO1

HGNC Gene Group: Ig-like cell adhesion molecule family, Fibronectin type III domain containing, Immunoglobulin superfamily domain containing

Functional Annotations for ROBO1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ROBO1

NCAM1 — ROBO1 ・ SLIT1 — ROBO1 ・ ROBO1 — ROBO1 ・ SLIT3 — ROBO1 ・ ROBO2 — ROBO1 ・ ROBO3 — ROBO1