CDB20:0002889 ROBO1 — ROBO1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Robo1 and Robo2 are homophilic binding molecules that promote axonal growth.

Molecular and cellular neurosciences, 2002; PubMed, Homo sapiens ROBO1 — Homo sapiens ROBO1

ABSTRACT: In the present study we show that following transfection in 3T3 cells, human Robo1 and Robo2 stimulate neurite outgrowth from Robo-positive neurons (retinal neurons and olfactory neurons), but have no effect on Robo-negative neurons (cerebellar granule cells). The neurite outgrowth response was inhibited by an antibody raised against the first Ig domain of Robo1/2 or by soluble Robo-Fc chimera. Furthermore, we show that the extracellular domains of Robo1 and Robo2 are homophilic adhesion molecules that can also interact with each other. These data suggest a wider range of functions for the Robo family in the development of the nervous system and provide novel insights into the molecular basis for the phenotypes observed in Robo mutants in Drosophila, C. elegans, and zebrafish.

Basic Information on ROBO1

Ligand Name: roundabout guidance receptor 1

Other Symbols: DUTT1, FLJ21882, SAX3

Ligand Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: ROBO1

GeneCards: ROBO1

HGNC Gene Group: Ig-like cell adhesion molecule family, Fibronectin type III domain containing, Immunoglobulin superfamily domain containing

Functional Annotations for ROBO1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for ROBO1

ROBO1 — ROBO2 ・ ROBO1 — ROBO3

Basic Information on ROBO1

Receptor Name: roundabout guidance receptor 1