CDB25:0004177 RELN — STAB2

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression.

Circulation, 2022; PubMed, Homo sapiens RELN — Homo sapiens STAB2

ABSTRACT: Scavenger receptors Stabilin-1 (Stab1) and Stabilin-2 (Stab2) are preferentially expressed by liver sinusoidal endothelial cells. They mediate the clearance of circulating plasma molecules controlling distant organ homeostasis. Studies suggest that Stab1 and Stab2 may affect atherosclerosis. Although subsets of tissue macrophages also express Stab1, hematopoietic Stab1 deficiency does not modulate atherogenesis. Here, we comprehensively studied how targeting Stab1 and Stab2 affects atherosclerosis.

Basic Information on RELN

Ligand Name: reelin

Other Symbols: RL, PRO1598

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: RELN

GeneCards: RELN

HGNC Gene Group: unknown

Functional Annotations for RELN

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for RELN

RELN — ITGA3 ・ RELN — ITGB1 ・ RELN — LRP8 ・ RELN — VLDLR ・ RELN — EFNB3 ・ RELN — ITGA2B ・ RELN — ITGB3

Basic Information on STAB2

Receptor Name: stabilin 2

Other Symbols: DKFZP434E0321, FELL, STAB-2, HARE, FEEL-2, SCARH1

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: STAB2

GeneCards: STAB2

HGNC Gene Group: Scavenger receptors

Functional Annotations for STAB2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for STAB2

POSTN — STAB2 ・ TGFBI — STAB2 ・ VWF — STAB2