CDB15:0001290 RELN — ITGA3

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Reelin binds alpha3beta1 integrin and inhibits neuronal migration.

Neuron, 2000; PubMed, Mus Musculus Reln — Mus Musculus Itga3

ABSTRACT: Mice that are mutant for Reelin or Dab1, or doubly mutant for the VLDL receptor (VLDLR) and ApoE receptor 2 (ApoER2), show disorders of cerebral cortical lamination. How Reelin and its receptors regulate laminar organization of cerebral cortex is unknown. We show that Reelin inhibits migration of cortical neurons and enables detachment of neurons from radial glia. Recombinant and native Reelin associate with alpha3beta1 integrin, which regulates neuron-glia interactions and is required to achieve proper laminar organization. The effect of Reelin on cortical neuronal migration in vitro and in vivo depends on interactions between Reelin and alpha3beta1 integrin. Absence of alpha3beta1 leads to a reduction of Dab1, a signaling protein acting downstream of Reelin. Thus, Reelin may arrest neuronal migration and promote normal cortical lamination by binding alpha3beta1 integrin and modulating integrin-mediated cellular adhesion.

Basic Information on RELN

Ligand Name: reelin

Other Symbols: RL, PRO1598

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: RELN

GeneCards: RELN

HGNC Gene Group: unknown

Functional Annotations for RELN

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for RELN

RELN — ITGB1 ・ RELN — LRP8 ・ RELN — VLDLR ・ RELN — EFNB3 ・ RELN — ITGA2B ・ RELN — ITGB3 ・ RELN — STAB2

Basic Information on ITGA3

Receptor Name: integrin subunit alpha 3

Other Symbols: MSK18, CD49c, VLA3a, VCA-2, GAP-B3

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: ITGA3

GeneCards: ITGA3

HGNC Gene Group: CD molecules, Integrins

Functional Annotations for ITGA3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ITGA3

ADAM9 — ITGA3 ・ FN1 — ITGA3 ・ LAMA4 — ITGA3 ・ LAMA5 — ITGA3 ・ LAMB1 — ITGA3 ・ LAMB3 — ITGA3 ・ LAMC1 — ITGA3 ・ LAMC2 — ITGA3 ・ NID1 — ITGA3 ・ THBS1 — ITGA3 ・ TIMP2 — ITGA3 ・ CSPG4 — ITGA3 ・ LAMA3 — ITGA3 ・ LGALS8 — ITGA3