CDB15:0001040 LTA — TNFRSF1A

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.

Cell, 1993; PubMed, Homo sapiens LTA — Homo sapiens TNFRSF1A

ABSTRACT: The X-ray crystal structure of the complex of the extracellular domain of the human 55 kd tumor necrosis factor (TNF) receptor with human TNF beta has been determined at 2.85 A resolution. The complex has three receptor molecules bound symmetrically to one TNF beta trimer. The receptor fragment, a very elongated end to end assembly of four similar folding domains, binds in the groove between two adjacent TNF beta subunits. The structure of the complex defines the orientation of the ligand with respect to the cell membrane and provides a model for TNF receptor activation. The novel fold of the TNF receptor structure is likely to be representative of the nerve growth factor (NGF)/TNF receptor family as a whole.

Basic Information on LTA

Ligand Name: lymphotoxin alpha

Other Symbols: TNFB, TNFSF1, LT

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: LTA

GeneCards: LTA

HGNC Gene Group: Receptor ligands: Tumor necrosis factor superfamily

Functional Annotations for LTA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LTA

LTA — LTBR ・ LTA — TNFRSF14 ・ LTA — TNFRSF1B

Basic Information on TNFRSF1A

Receptor Name: TNF receptor superfamily member 1A

Other Symbols: TNFR1, TNF-R, TNFAR, TNFR60, TNF-R-I, CD120a, TNF-R55

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: TNFRSF1A

GeneCards: TNFRSF1A

HGNC Gene Group: CD molecules, Tumor necrosis factor receptor superfamily

Functional Annotations for TNFRSF1A

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TNFRSF1A

LTB — TNFRSF1A ・ TNFSF13 — TNFRSF1A ・ TNF — TNFRSF1A ・ GRN — TNFRSF1A ・ ADAM17 — TNFRSF1A ・ PGLYRP1 — TNFRSF1A