CDB15:0001039 LTA — TNFRSF14

Experimentally validated in Human; Orthology-inferred in Rat, Frog, Macaque, Dog, Chimp, Marmoset

Title

Journal:; Year Published:

Abstract

LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator.

Immunity, 1998; PubMed, Homo sapiens LTA — Homo sapiens TNFRSF14

ABSTRACT: Herpes simplex virus (HSV) 1 and 2 infect activated T lymphocytes by attachment of the HSV envelope glycoprotein D (gD) to the cellular herpesvirus entry mediator (HVEM), an orphan member of the tumor necrosis factor receptor superfamily. Here, we demonstrate that HVEM binds two cellular ligands, secreted lymphotoxin alpha (LTalpha) and LIGHT, a new member of the TNF superfamily. LIGHT is a 29 kDa type II transmembrane protein produced by activated T cells that also engages the receptor for the LTalphabeta heterotrimer but does not form complexes with either LTalpha or LTbeta. HSV1 gD inhibits the interaction of HVEM with LIGHT, and LIGHT and gD interfere with HVEM-dependent cell entry by HSV1. This characterizes herpesvirus gD as a membrane-bound viokine and establishes LIGHT-HVEM as integral components of the lymphotoxin cytokine-receptor system.

Basic Information on LTA

Ligand Name: lymphotoxin alpha

Other Symbols: TNFB, TNFSF1, LT

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: LTA

GeneCards: LTA

HGNC Gene Group: Receptor ligands: Tumor necrosis factor superfamily

Functional Annotations for LTA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LTA

LTA — LTBR ・ LTA — TNFRSF1A ・ LTA — TNFRSF1B

Basic Information on TNFRSF14

Receptor Name: TNF receptor superfamily member 14

Other Symbols: HVEM, ATAR, TR2, LIGHTR, HVEA, CD270

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: TNFRSF14

GeneCards: TNFRSF14

HGNC Gene Group: CD molecules, Tumor necrosis factor receptor superfamily

Functional Annotations for TNFRSF14

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for TNFRSF14

BTLA — TNFRSF14 ・ TNFSF13 — TNFRSF14 ・ TNFSF14 — TNFRSF14 ・ CD160 — TNFRSF14