CDB25:0003926 LRRTM3 — NRXN1

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding.

Cell reports, 2016; PubMed, Mus Musculus Lrrtm3 — Mus Musculus Nrxn1

ABSTRACT: The four members of the LRRTM family (LRRTM1-4) are postsynaptic adhesion molecules essential for excitatory synapse development. They have also been implicated in neuropsychiatric diseases. Here, we focus on LRRTM3, showing that two distinct LRRTM3 variants generated by alternative splicing regulate LRRTM3 interaction with PSD-95, but not its excitatory synapse-promoting activity. Overexpression of either LRRTM3 variant increased excitatory synapse density in dentate gyrus (DG) granule neurons, whereas LRRTM3 knockdown decreased it. LRRTM3 also controlled activity-regulated AMPA receptor surface expression in an alternative splicing-dependent manner. Furthermore, Lrrtm3-knockout mice displayed specific alterations in excitatory synapse density, excitatory synaptic transmission and excitability in DG granule neurons but not in CA1 pyramidal neurons. Lastly, LRRTM3 required only specific splice variants of presynaptic neurexins for their synaptogenic activity. Collectively, our data highlight alternative splicing and differential presynaptic ligand utilization in the regulation of LRRTMs, revealing key regulatory mechanisms for excitatory synapse development.

Basic Information on LRRTM3

Ligand Name: leucine rich repeat transmembrane neuronal 3

Other Symbols: N/A

Ligand Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: LRRTM3

GeneCards: LRRTM3

HGNC Gene Group: unknown

Functional Annotations for LRRTM3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LRRTM3

Basic Information on NRXN1

Receptor Name: neurexin 1

Other Symbols: KIAA0578, Hs.22998

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: NRXN1

GeneCards: NRXN1

HGNC Gene Group: Neurexins, MicroRNA host genes

Functional Annotations for NRXN1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for NRXN1

NLGN1 — NRXN1 ・ NLGN2 — NRXN1 ・ NLGN3 — NRXN1 ・ NXPH1 — NRXN1 ・ NXPH3 — NRXN1 ・ NLGN4X — NRXN1 ・ ADGRL1 — NRXN1 ・ CBLN1 — NRXN1 ・ CBLN2 — NRXN1 ・ CLSTN3 — NRXN1 ・ DAG1 — NRXN1 ・ LRRTM1 — NRXN1 ・ LRRTM2 — NRXN1 ・ LRRTM4 — NRXN1 ・ TAFA1 — NRXN1 ・ TAFA2 — NRXN1 ・ TAFA3 — NRXN1 ・ TAFA4 — NRXN1