CDB25:0003236 CBLN1 — NRXN1

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum.

Cell, 2010; PubMed, Mus Musculus Cbln1 — Mus Musculus Nrxn1

ABSTRACT: Elucidation of molecular mechanisms that regulate synapse formation is required for the understanding of neural wiring, higher brain functions, and mental disorders. Despite the wealth of in vitro information, fundamental questions about how glutamatergic synapses are formed in the mammalian brain remain unanswered. Glutamate receptor (GluR) delta2 is essential for cerebellar synapse formation in vivo. Here, we show that the N-terminal domain (NTD) of GluRdelta2 interacts with presynaptic neurexins (NRXNs) through cerebellin 1 precursor protein (Cbln1). The synaptogenic activity of GluRdelta2 is abolished in cerebellar primary cultures from Cbln1 knockout mice and is restored by recombinant Cbln1. Knockdown of NRXNs in cerebellar granule cells also hinders the synaptogenic activity of GluRdelta2. Both the NTD of GluRdelta2 and the extracellular domain of NRXN1beta suppressed the synaptogenic activity of Cbln1 in cerebellar primary cultures and in vivo. These results suggest that GluRdelta2 mediates cerebellar synapse formation by interacting with presynaptic NRXNs through Cbln1.

Basic Information on CBLN1

Ligand Name: cerebellin 1 precursor

Other Symbols: N/A

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on uniprot

HGNC Gene Symbol Report: CBLN1

GeneCards: CBLN1

HGNC Gene Group: C1q domain containing

Functional Annotations for CBLN1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CBLN1

CBLN1 — GRID2 ・ CBLN1 — NRXN2 ・ CBLN1 — NRXN3

Basic Information on NRXN1

Receptor Name: neurexin 1

Other Symbols: KIAA0578, Hs.22998

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: NRXN1

GeneCards: NRXN1

HGNC Gene Group: Neurexins, MicroRNA host genes

Functional Annotations for NRXN1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for NRXN1

NLGN1 — NRXN1 ・ NLGN2 — NRXN1 ・ NLGN3 — NRXN1 ・ NXPH1 — NRXN1 ・ NXPH3 — NRXN1 ・ NLGN4X — NRXN1 ・ ADGRL1 — NRXN1 ・ CBLN2 — NRXN1 ・ CLSTN3 — NRXN1 ・ DAG1 — NRXN1 ・ LRRTM1 — NRXN1 ・ LRRTM2 — NRXN1 ・ LRRTM3 — NRXN1 ・ LRRTM4 — NRXN1 ・ TAFA1 — NRXN1 ・ TAFA2 — NRXN1 ・ TAFA3 — NRXN1 ・ TAFA4 — NRXN1