CDB25:0003917 LRPAP1 — IFNAR1

Experimentally validated in Human, Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep, Zebrafish

Title

Journal:; Year Published:

Abstract

Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity.

Signal transduction and targeted therapy, 2023; PubMed, Homo sapiens LRPAP1 — Homo sapiens IFNAR1

ABSTRACT: The crucial role of interferon (IFN) signaling is well known in the restriction or eradication of pathogen invasion. Viruses take a variety of ways to antagonize host defense through eliminating IFN-signaling intracellularly for decades. However, the way by viruses target IFN-signaling extracellularly has not been discovered. Infection by both coronavirus SARS-CoV-2 and enterovirus 71 (EV71 or EV-A71) can cause severe diseases such as neurological disorders and even death in children.

Basic Information on LRPAP1

Ligand Name: LDL receptor related protein associated protein 1

Other Symbols: A2MRAP, RAP, HBP44, Alpha-2-MRAP

Ligand Location: secreted based on perplexity

HGNC Gene Symbol Report: LRPAP1

GeneCards: LRPAP1

HGNC Gene Group: unknown

Functional Annotations for LRPAP1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LRPAP1

LRPAP1 — LDLR ・ LRPAP1 — LRP1 ・ LRPAP1 — LRP2

Basic Information on IFNAR1

Receptor Name: interferon alpha and beta receptor subunit 1

Other Symbols: IFNAR, IFRC

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: IFNAR1

GeneCards: IFNAR1

HGNC Gene Group: Interferon receptors

Functional Annotations for IFNAR1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for IFNAR1

IFNA10 — IFNAR1 ・ IFNA14 — IFNAR1 ・ IFNA16 — IFNAR1 ・ IFNA17 — IFNAR1 ・ IFNA1 — IFNAR1 ・ IFNA21 — IFNAR1 ・ IFNA2 — IFNAR1 ・ IFNA4 — IFNAR1 ・ IFNA5 — IFNAR1 ・ IFNA6 — IFNAR1 ・ IFNA7 — IFNAR1 ・ IFNA8 — IFNAR1 ・ IFNB1 — IFNAR1 ・ IFNW1 — IFNAR1 ・ IFNE — IFNAR1 ・ IFNK — IFNAR1 ・ MMP9 — IFNAR1