CDB25:0003910 LRFN5 — PTPRD

Experimentally validated in Human, Mouse; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep, Mouse

Title

Journal:; Year Published:

Abstract

SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development.

Scientific reports, 2016; PubMed, Homo sapiens LRFN5 — Homo sapiens PTPRD

ABSTRACT: Synaptogenic adhesion molecules play critical roles in synapse formation. SALM5/Lrfn5, a SALM/Lrfn family adhesion molecule implicated in autism spectrum disorders (ASDs) and schizophrenia, induces presynaptic differentiation in contacting axons, but its presynaptic ligand remains unknown. We found that SALM5 interacts with the Ig domains of LAR family receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPδ, and PTPσ). These interactions are strongly inhibited by the splice insert B in the Ig domain region of LAR-RPTPs, and mediate SALM5-dependent presynaptic differentiation in contacting axons. In addition, SALM5 regulates AMPA receptor-mediated synaptic transmission through mechanisms involving the interaction of postsynaptic SALM5 with presynaptic LAR-RPTPs. These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory synaptic strength.

Basic Information on LRFN5

Ligand Name: leucine rich repeat and fibronectin type III domain containing 5

Other Symbols: C14orf146, FIGLER8, SALM5

Ligand Location: cell membrane based on perplexity

HGNC Gene Symbol Report: LRFN5

GeneCards: LRFN5

HGNC Gene Group: Ig-like cell adhesion molecule family, Fibronectin type III domain containing, Immunoglobulin superfamily domain containing

Functional Annotations for LRFN5

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LRFN5

LRFN5 — LRFN5 ・ LRFN5 — PTPRF ・ LRFN5 — PTPRS

Basic Information on PTPRD

Receptor Name: protein tyrosine phosphatase receptor type D

Other Symbols: PTPD, HPTP

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: PTPRD

GeneCards: PTPRD

HGNC Gene Group: Phosphatases, LAR (PTPRF) protein receptor tyrosine phosphatase family, Fibronectin type III domain containing, Immunoglobulin superfamily domain containing

Functional Annotations for PTPRD

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for PTPRD

IL1RAPL1 — PTPRD ・ LRRC4B — PTPRD ・ SLITRK1 — PTPRD ・ SLITRK2 — PTPRD ・ SLITRK3 — PTPRD ・ SLITRK5 — PTPRD ・ IL1RAP — PTPRD ・ LRFN4 — PTPRD ・ NLGN3 — PTPRD ・ OMG — PTPRD