CDB25:0003907 LRFN4 — PTPRD

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion.

Cell reports, 2015; PubMed, Homo sapiens LRFN4 — Mus Musculus Ptprd

ABSTRACT: Synaptic adhesion molecules regulate diverse aspects of synapse development and plasticity. SALM3 is a PSD-95-interacting synaptic adhesion molecule known to induce presynaptic differentiation in contacting axons, but little is known about its presynaptic receptors and in vivo functions. Here, we identify an interaction between SALM3 and LAR family receptor protein tyrosine phosphatases (LAR-RPTPs) that requires the mini-exon B splice insert in LAR-RPTPs. In addition, SALM3-dependent presynaptic differentiation requires all three types of LAR-RPTPs. SALM3 mutant (Salm3(-/-)) mice display markedly reduced excitatory synapse number but normal synaptic plasticity in the hippocampal CA1 region. Salm3(-/-) mice exhibit hypoactivity in both novel and familiar environments but perform normally in learning and memory tests administered. These results suggest that SALM3 regulates excitatory synapse development and locomotion behavior.

Basic Information on LRFN4

Ligand Name: leucine rich repeat and fibronectin type III domain containing 4

Other Symbols: MGC3103, SALM3., FIGLER6

Ligand Location: cell membrane based on perplexity

HGNC Gene Symbol Report: LRFN4

GeneCards: LRFN4

HGNC Gene Group: Ig-like cell adhesion molecule family, Fibronectin type III domain containing, Immunoglobulin superfamily domain containing

Functional Annotations for LRFN4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LRFN4

LRFN4 — PTPRF ・ LRFN4 — PTPRS

Basic Information on PTPRD

Receptor Name: protein tyrosine phosphatase receptor type D

Other Symbols: PTPD, HPTP

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: PTPRD

GeneCards: PTPRD

HGNC Gene Group: Phosphatases, LAR (PTPRF) protein receptor tyrosine phosphatase family, Fibronectin type III domain containing, Immunoglobulin superfamily domain containing

Functional Annotations for PTPRD

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for PTPRD

IL1RAPL1 — PTPRD ・ LRRC4B — PTPRD ・ SLITRK1 — PTPRD ・ SLITRK2 — PTPRD ・ SLITRK3 — PTPRD ・ SLITRK5 — PTPRD ・ IL1RAP — PTPRD ・ LRFN5 — PTPRD ・ NLGN3 — PTPRD ・ OMG — PTPRD