CDB20:0002813 LGALS9 — HAVCR2

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.

Nature immunology, 2005; PubMed, Mus Musculus Lgals9 — Mus Musculus Havcr2

ABSTRACT: Tim-3 is a T helper type 1 (T(H)1)-specific cell surface molecule that seems to regulate T(H)1 responses and the induction of peripheral tolerance. However, the identity of the Tim-3 ligand and the mechanism by which this ligand inhibits the function of effector T(H)1 cells remain unknown. Here we show that galectin-9 is the Tim-3 ligand. Galectin-9-induced intracellular calcium flux, aggregation and death of T(H)1 cells were Tim-3-dependent in vitro, and administration of galectin-9 in vivo resulted in selective loss of interferon-gamma-producing cells and suppression of T(H)1 autoimmunity. These data suggest that the Tim-3-galectin-9 pathway may have evolved to ensure effective termination of effector T(H)1 cells.

Basic Information on LGALS9

Ligand Name: galectin 9

Other Symbols: LGALS9A

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: LGALS9

GeneCards: LGALS9

HGNC Gene Group: Receptor ligands, Galectins

Functional Annotations for LGALS9

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LGALS9

LGALS9 — CD44 ・ LGALS9 — BCR ・ LGALS9 — CD180 ・ LGALS9 — CD40 ・ LGALS9 — CLEC7A ・ LGALS9 — IGHM ・ LGALS9 — PTPRC ・ LGALS9 — TLR4 ・ LGALS9 — VSIR

Basic Information on HAVCR2

Receptor Name: hepatitis A virus cellular receptor 2

Other Symbols: Tim-3, TIM3, FLJ14428, TIMD3, CD366

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: HAVCR2

GeneCards: HAVCR2

HGNC Gene Group: Immunoglobulin superfamily domain containing

Functional Annotations for HAVCR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for HAVCR2

CEACAM1 — HAVCR2 ・ HMGB1 — HAVCR2