CDB25:0003899 LGALS9 — CLEC7A

Experimentally validated in Human, Mixed species; Orthology-inferred in Human, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance.

Nature medicine, 2017; PubMed, Homo sapiens LGALS9 — Homo sapiens CLEC7A
ABSTRACT: The progression of pancreatic oncogenesis requires immune-suppressive inflammation in cooperation with oncogenic mutations. However, the drivers of intratumoral immune tolerance are uncertain. Dectin 1 is an innate immune receptor crucial for anti-fungal immunity, but its role in sterile inflammation and oncogenesis has not been well defined. Furthermore, non-pathogen-derived ligands for dectin 1 have not been characterized. We found that dectin 1 is highly expressed on macrophages in pancreatic ductal adenocarcinoma (PDA). Dectin 1 ligation accelerated the progression of PDA in mice, whereas deletion of Clec7a-the gene encoding dectin 1-or blockade of dectin 1 downstream signaling was protective. We found that dectin 1 can ligate the lectin galectin 9 in mouse and human PDA, which results in tolerogenic macrophage programming and adaptive immune suppression. Upon disruption of the dectin 1-galectin 9 axis, CD4
Basic Information on LGALS9
Ligand Name: galectin 9
Other Symbols: LGALS9A
Ligand Location: secreted based on hpa, perplexity, uniprot
HGNC Gene Symbol Report: LGALS9
GeneCards: LGALS9
HGNC Gene Group: Receptor ligands, Galectins
Functional Annotations for LGALS9
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Receptors for LGALS9
LGALS9 — CD44 ・ LGALS9 — HAVCR2 ・ LGALS9 — BCR ・ LGALS9 — CD180 ・ LGALS9 — CD40 ・ LGALS9 — IGHM ・ LGALS9 — PTPRC ・ LGALS9 — TLR4 ・ LGALS9 — VSIR
Basic Information on CLEC7A
Receptor Name: C-type lectin domain containing 7A
Other Symbols: CLECSF12, DECTIN-1, hDectin-1, CD369, SCARE2
Receptor Location: cell membrane based on perplexity, uniprot
HGNC Gene Symbol Report: CLEC7A
GeneCards: CLEC7A
Functional Annotations for CLEC7A
Gene Ontologies: PAN-GO, AmiGO 2
Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)
Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)
Interactions with other Ligands for CLEC7A
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