CDB25:0003872 LGALS1 — CD7

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Sheep

Title

Journal:; Year Published:

Abstract

CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death.

Journal of immunology, 2000; PubMed, Homo sapiens LGALS1 — Homo sapiens CD7

ABSTRACT: Galectin-1, an endogenous lectin expressed in lymphoid organs and immune-privileged sites, induces death of human and murine thymocytes and T cells. Galectin-1 binds to several glycoproteins on the T cell surface, including CD7. However, the T cell surface glycoprotein receptors responsible for delivering the galectin-1 death signal have not been identified. We show that CD7 is required for galectin-1-mediated death. This demonstrates a novel function for CD7 as a death trigger and identifies galectin-1/CD7 as a new biologic death signaling pair.

Basic Information on LGALS1

Ligand Name: galectin 1

Other Symbols: GBP

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: LGALS1

GeneCards: LGALS1

HGNC Gene Group: Receptor ligands, Galectins

Functional Annotations for LGALS1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LGALS1

LGALS1 — CD69 ・ LGALS1 — ITGB1 ・ LGALS1 — PTPRC

Basic Information on CD7

Receptor Name: CD7 molecule

Other Symbols: GP40, LEU-9, TP41, Tp40

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: CD7

GeneCards: CD7

HGNC Gene Group: CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for CD7

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD7

SECTM1 — CD7