CDB25:0003864 LAMC1 — DAG1

Experimentally validated in Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11.

FEBS letters, 2006; PubMed, Mus Musculus Lamc1 — Bos taurus DAG1

ABSTRACT: alpha-Dystroglycan was quantitatively enriched from mammalian brain based on its uniform reactivity with Vicia villosa agglutinin and resolved into sub-populations possessing or lacking the sulfated glucuronic acid epitope recognized by monoclonal antibody HNK-1. We generated a new monoclonal antibody specific for a glycoepitope on brain alpha-dystroglycan but absent from alpha-dystroglycan expressed in all other tissues examined. Finally, we found that laminin-10/11 preferentially bound to brain alpha-dystroglycan compared to skeletal muscle alpha-dystroglycan. Our results suggest that tissue-specific glycosylation modifies the laminin binding specificity of alpha-dystroglycan.

Basic Information on LAMC1

Ligand Name: laminin subunit gamma 1

Other Symbols: LAMB2

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: LAMC1

GeneCards: LAMC1

HGNC Gene Group: Laminin subunits

Functional Annotations for LAMC1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for LAMC1

LAMC1 — ITGA3 ・ LAMC1 — ITGA6 ・ LAMC1 — ITGA7 ・ LAMC1 — ITGB1 ・ LAMC1 — ITGB4 ・ LAMC1 — PTPRF

Basic Information on DAG1

Receptor Name: dystroglycan 1

Other Symbols: A3a, 156DAG, AGRNR, DAG

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: DAG1

GeneCards: DAG1

HGNC Gene Group: unknown

Functional Annotations for DAG1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for DAG1

AGRN — DAG1 ・ LAMA2 — DAG1 ・ HSPG2 — DAG1 ・ LAMA1 — DAG1 ・ LAMA4 — DAG1 ・ LAMA5 — DAG1 ・ LAMB1 — DAG1 ・ LAMB2 — DAG1 ・ NRXN1 — DAG1 ・ NRXN2 — DAG1 ・ NRXN3 — DAG1